应用羟基磷灰石生物陶瓷及口腔膜引导骨再生修复牙周骨缺损  

Coralline hydroxyapatite combined with guided bone regeneration for repairing alveolar bone defects

作　　者：戴晓玮[1] 阮晓慧[2] 尼加提.吐尔逊 

机构地区：[1]新疆医科大学口腔系,新疆维吾尔自治区乌鲁木齐市830054 [2]新疆医科大学第二临床医学院口腔科,新疆维吾尔自治区乌鲁木齐市830063

出　　处：《中国组织工程研究》2012年第43期8032-8036,共5页Chinese Journal of Tissue Engineering Research

基　　金：新疆维吾尔自治区自然科学基金资助项目(2012211A029)~~

摘　　要：背景:羟基磷灰石生物陶瓷以天然优质海洋珊瑚为原料,在珊瑚骨架上形成羟基磷灰石薄层,保留珊瑚天然孔孔相同的支架结构,为组织生长提供了良好空间。目的:观察羟基磷灰石生物陶瓷膜引导骨再生修复牙周骨缺损的临床效果。方法:将42例下颌第一磨牙牙周病致骨缺损患者随机分组:实验组采用羟基磷灰石生物陶瓷结合口腔修复膜充填修复骨缺损,对照组采用单独羟基磷灰石生物陶瓷充填修复。结果与结论:临床随访观察12个月,两组牙周组织附着丧失、牙周探诊深度较治疗前明显改善(P<0.05),且实验组牙周组织附着丧失、牙周探诊深度改善优于对照组(P<0.05);实验组骨缺损区新骨形成密度和骨量均优于对照组(P<0.05)。表明采用羟基磷灰石生物陶瓷充填骨缺损区同时覆盖生物膜的引导骨再生技术可获得良好的骨引导再生效果,修复骨缺损。BACKGROUND： The coralline hydroxyapatite is take high quality natural narine biological as raw materials. It forms hydroxyapatite thin layer in coral skeleton, so it keeps natural coral distributed framework, thereby providing a good space for tissue growth. OBJECTIVE： To investigate the clinical effect of coralline hydroxyapatite on guiding bone regeneration for the repair of alveolar bone defects. METHODS： Forty-two patients with bone defects caused by mandibular first molar periodontitis were collected and randomly divided into experimental group and control group. Patients in the experimental group were treated with coralline hydroxyapatite combined with oral biofilm to fill and repair bone defects, and those in the control group were only treated with coralline hydroxyapatite. RESULTS AND CONCLUSION： The patients were followed up for 12 months and the results showed that periodontal attachment loss was found in the two groups, besides, periodontal probing depth was improved obviousty after treatment （P 〈 0.05）. In addition, compared with the control group, periodontal attachment loss and periodontal probing depth in the experimental group were better （P 〈 0.05）. Moreover, new bone formation density and bone mass of the experimental group were superior to those of the control group （P 〈 0.05）. These results suggest that coralline hydroxyapatite combined with guided bone regeneration technique can have good effect on guiding bone regeneration and repair bone defects.

关 键 词：羟基磷灰石生物陶瓷 口腔生物膜 引导骨再生 牙周骨缺损 口腔生物材料 

分 类 号：R318[医药卫生—生物医学工程]