疑因镍铬合金烤瓷牙致白细胞数降低的病例分析  

Leukocyte reduction associated with Ni-Cr alloy porcelain crown:A case analysis

作　　者：樊灿灿[1] 安晓莉[1] 车小强[1] 刘斌[1] 

机构地区：[1]兰州大学口腔医学院,甘肃省兰州市730000

出　　处：《中国组织工程研究》2012年第43期8168-8170,共3页Chinese Journal of Tissue Engineering Research

基　　金：兰州大学政科研基金项目(2011-5);兰州大学学生创新创业行动计划项目(2009-141);中央高校基本科研业务费专项资金(lzujbky-2011-96)~~

摘　　要：背景:镍铬合金烤瓷牙可引起过敏反应,其对全身脏器和功能的影响引起学者们的关注,尤其是对于肾脏和免疫系统的影响。目的:针对临床中发现的1例疑因镍铬合金烤瓷牙导致白细胞数降低,进行报告和分析,探讨镍铬合金烤瓷牙对免疫系统的影响。方法:对临床发现的特殊病例,检查全身和口腔状况,拆除可能致病的修复体,进行相关治疗后行全瓷冠修复,1个月后复查并对比治疗前后的血象。通过查阅文献资料分析镍铬合金烤瓷牙引起白细胞数降低的可能性。结果与结论:从镍铬合金烤瓷牙的拆除及全瓷冠修复后的白细胞数改变,验证了镍铬合金烤瓷牙致白细胞数降低的推测。资料也表明镍铬合金烤瓷牙可通过一定途径对免疫功能产生影响,这应当引起口腔工作者的注意,采取一定措施,避免不良后果。BACKGROUND： It is known that Ni-Cr alloy porcelain crown can cause allergic reactions. Recently, their effects to whole body organs and functions also have attracted scholars＇ attention, especially for the influence on the kidney and immune system. OBJECTIVE： To report and analyze a clinical suspected case of lower white blood cell count due to the Ni-Cr alloy porcelain crown, and to discuss the impact of Ni-Cr alloy porcelain crown on the immune system. METHODS： According to the clinical special case, we inspected the general and oral conditions and removed the prosthesis which might cause diseases. Then we treated the related disease and restored the teeth with full porcelain crown. After a month, the patient came back for review and we compared the results of hemogram before and after treatment. Referring to literatures, we also analyzed the possibility of white blood cell count reduction caused by Ni-Cr alloy porcelain crown. RESULTS AND CONCLUSION： The change of white blood cell count after the removal of Ni-Cr alloy porcelain crown and all-ceramic crowns restoration could verify the conjecture that the Ni-Cr alloy porcelain crown caused the reduction of white blood cell count. The data also showed that the Ni-Cr alloy porcelain crown could influence the immune function through certain ways, which should arouse the attention of dental doctors. Therefore we should take certain measures to avoid these negative effects.

关 键 词：镍铬合金烤瓷牙 白细胞 过敏反应 血象 生物材料 

分 类 号：R318[医药卫生—生物医学工程]