TNFRSF11B基因多态性与肌肉量的关系  

Association of TNFRSF11B Polymorphism with Lean Muscle Mass in Population of Chinese Han

作　　者：王静[1] 李响[1] 解端阳[1] 陈艳[2] 蒋晓燕[1] 

机构地区：[1]同济大学医学院,心脏病基础研究教育部重点实验室,上海市200092 [2]济南市妇幼保健院妇科内分泌,山东济南市250001

出　　处：《中国康复理论与实践》2012年第11期1029-1032,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金青年基金(No.81100551);上海市自然科学基金(No.11ZR1438600);济南市科学技术发展计划项目(No.200807031)

摘　　要：目的研究TNFRSF11B基因多态性对人肌肉量的影响。方法对419名汉族健康志愿者测量全身、躯干、上肢、下肢的肌肉量,采用标签单核苷酸多态性(tSNP)策略选择8个tSNP,进行基因分型。结果 TNFRSF11B基因rs2875845位点AA、AG和GG以及rs1485288位点CC、CT和TT基因型携带者个体左右侧上肢、下肢、躯干肌肉量和全身肌肉量依次增加(P<0.05)。结论TNFRSF11B基因rs2875845位点的G等位基因及rs1485288位点的T等位基因增加汉族人肌肉量的水平。Objective To investigate the association of the TNFRSF 11B gene polymorphism and the lean muscle mass in population of Chinese Han living in Jinan. Methods Lean muscle mass of 419 volunteers were measured with dual energy X-ray absorptiometry. 8 tagging single nucleotide polymorphism （tSNP） of TNFRSFllB gene were genotyped. Results Lean muscle mass of whole body increased with the copy of the G allele of TNFRSF11B-rs2875845 and the T allele of TNFRSF11B-rs1485288 （P〈0.05）. Conclusion The G allele of rs2875845 and the T allele ofrs1485288 in TNFRSF11B gene increase the level of the lean muscle mass in Chinese Han population.

关 键 词：TNFRSF11B基因 单核苷酸多态性 肌肉量 

分 类 号：R336[医药卫生—人体生理学]