电针联合依达拉奉对糖尿病周围神经病大鼠坐骨神经传导速度和氧化应激的影响  

Effect of Electroacupuncture Combined with Edaravone on Conduction Velocity of Sciatic Nerve and Oxidative Stress in Rats with Diabetic Peripheral Neuropathy

作　　者：邱有波[1] 谢少华[1] 杨拯[1] 袁梦郎[1] 李禹呈[1] 江明礼[1] 曹德琦[1] 席丽[1] 张晓[1] 

机构地区：[1]成都医学院,四川成都市610081

出　　处：《中国康复理论与实践》2012年第11期1036-1039,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：成都医学院综合性;设计性实验项目基金资助(ZH2010015;ZH2010009)

摘　　要：目的观察电针联合依达拉奉对糖尿病周围神经病大鼠坐骨神经传导速度和氧化应激的影响。方法 SD大鼠60只,选取10只作为正常组。其余予一次性链脲佐菌素腹腔注射造模。抽取48只模型大鼠,分为电针组、依达拉奉组、联合组和模型组各12只。造模后4周、8周,测试各大鼠摆尾阈值、血清超氧化物酶歧化酶(SOD)活性和丙二醛(MDA)浓度及坐骨神经传导速度。结果造模8周时,电针组、依达拉奉组和联合组运动神经传导速度明显高于模型组(P<0.01),SOD活性明显高于模型组(P<0.01),MDA浓度明显低于模型组(P<0.01);而联合组明显优于电针组、依达拉奉组(P<0.01)。结论电针及依达拉奉均能有效抑制糖尿病周围神经病大鼠的氧化应激反应,改善坐骨神经传导速度,联合应用效果更佳。Objective To observe the effects of electroacupuncture combined with edaravone on the conduction velocity of sciatic nerve and oxidative stress in rats with diabetic peripheral neuropathy. Methods 60 Sprague Dawley （SD） rats were included. 10 of them were selected as normal group. The other rats were modeled as diabetic peripheral neuropathy with streptozotocin. 48 of them were randomly selected and divided into electroacupuncture group （n=12）, edaravone group （n=12）, electroaeupuncture＋edaravone group （n=12）, and model group （n=12）. The threshold temperature for wave tail was tested, the levels of superoxidase dismutase （SOD） and malonaldehyde （MDA） were determined, and the conduction velocity of sciatic nerve were measured, before, and 4 and 8 weeks after modeling. Results 8 weeks af- ter modeling, the conduction velocity and SOD increased in the electroacupuncture group, edaravone group and electroaeupuncture＋edaravone group compared with the model group （P〈0.01）, with the MDA decrease （P〈0.01）, while it was improved more in the electroacupuneture＋edaravone group than in the clectroacupuncture group or the edaravone group （P〈0.01）. Conclusion Both electroacupuncture and edaravone can inhibit oxidative stress and improve nerve conduction velocity of the sciatic nerve in rats with diabetic peripheral neuropathy, and it is more effective of combination.

关 键 词：糖尿病周围神经病 电针 依达拉奉 氧化应激 神经传导速度 

分 类 号：R587.1[医药卫生—内分泌]