通络救脑注射液对阿尔茨海默病模型大鼠学习记忆及氧化应激反应的影响  被引量:6

Effects of Tongluo Jiunao Injection on learning and memory and oxidative stress response for Alzheimer′s Disease Rat Models

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作  者:刘洋[1] 李澎涛[2] 刘希伟[1] 南一楠[1] 都文渊[1] 

机构地区:[1]北京中医药大学基础医学院中西医结合基础(病理),北京110029 [2]北京中医药大学东直门医院,北京100700

出  处:《中医学报》2012年第12期1614-1616,共3页Acta Chinese Medicine

基  金:北京中医药大学自主课题(编号:2011-JYBZZ-XS077)

摘  要:目的:探讨通络救脑注射液(Tong Luo Jiu Nao injection,TLJN)对阿尔茨海默病(Alzheimer’s Disease,AD)模型大鼠的防治作用及其抗氧化机制。方法:采用脑内定位注射β淀粉样蛋白(βamyloid1-42)建立AD大鼠模型,在模型建立成功的同时给予TLJN治疗。采用Morris水迷宫进行AD大鼠的行为学检测,用化学比色法检测大脑皮质丙二醛(MDA)的含量。结果:与正常组比较,AD模型组大鼠的逃避潜伏期明显延长(P<0.01),目标象限停留时间明显缩短(P<0.01);TLJN治疗组大鼠逃避潜伏期明显缩短(P<0.05),目标象限停留时间明显增加(P<0.05)。AD模型组大鼠脑皮质中MDA含量增加(P<0.01);TLJN治疗组,脑皮质MDA含量显著减少(P<0.01)。结论:TLJN具有改善学习记忆能力,对抗大鼠神经系统的退行性病变有一定的作用,可能通过抑制AD模型大鼠脑皮质MDA产生发挥其保护作用。Objective:To explore the preventive and therapeutic effect and anti-oxidation mechanism of Tong Luo Jiu Nao injection (TLJN) in Alzheimer's Disease (AD)rat models. Methods:The AD rat model was established by injectingβ-amyloidl-42 into the rat brain, and successful model rats were given TLIN injection treatment at the same time. The behavioral changes of the AD rats were test- ed with Morris water maze. Chemical colorimetry was used to measure malondialdehyde (MDA) content in the cerebral cortex. Results : Compared with the control group,the escape latent period of AD rats was significantly longer (P 〈 0.01 ), retention time of the target quadrant significantly obviously reduced( P 〈 0.01 ) ; After TLJN treatment, the escape latent period of AD rats was significantly shorter (P 〈0.05) ,and retention time of the target quadrant was significantly inereased(P 〈0.05). In AD model group,the MDA content in cerebral cortex was increased signifieantly(P 〈 0.01 ) ;while after TLJN treatment, the MDA content in cerebral cortex was decreased obviously( P 〈0.01 ). Conclusions :TLJN treatment has certain effects on improving learning and memory ability of AD rats and resisting retrogression of rats nervous system,and plays protective role in AD rats possibly via inhibiting the production of MDA.

关 键 词:阿尔茨海默病 通络救脑注射液 MORRIS水迷宫 学习记忆 氧化应激反应 大鼠 

分 类 号:R285.5[医药卫生—中药学]

 

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