线性扫描极谱法测定盐酸吡硫醇  

Linear Scanning Polarographic Determination of Pyritinol Hydrochloride

作　　者：丘则海[1] 胡志彪[1] 周云龙[1] 拓宏桂[1] 

机构地区：[1]龙岩学院化学与材料学院,龙岩364000

出　　处：《理化检验（化学分册）》2012年第11期1280-1282,1285,共4页Physical Testing and Chemical Analysis(Part B:Chemical Analysis)

基　　金：福建省教育厅B类项目资助(JB09220)

摘　　要：用线性扫描极谱法研究盐酸吡硫醇的电化学行为,在pH 6.27的磷酸氢二钠-磷酸二氢钾缓冲溶液中,盐酸吡硫醇于-0.560V(vs·SCE)处产生一灵敏的吸附波,其一次微分线性扫描峰电流与盐酸吡硫醇质量浓度在0.10～100.0 mg·L-1范围内呈线性关系,检出限(3S/N)为0.07mg·L-1。对10.0mg·L-1盐酸吡硫醇溶液进行6次平行试验,相对标准偏差为0.82%,方法可用于片剂中盐酸吡硫醇含量的测定,所得结果与标示值相符。It was found that in a PBS of pH 6. 27 and by the linear scanning polarography, a sensitive adsorption wave of pyritinol hydrochloride was observed at the potential of -0. 560 V （vs. SCE）. Linear relationship between values of the 1st derivative of peak current and mass concentration of pyritinol hydrochloride was obtained in the range of 0. 1-100. 0 mg · L-1 with detection limit （3S/N） of 0. 07 mg · L-1. Precision was tested with standard solution of pyritinol hydrochloride of 10. 0 mg ·L -1for 6 determinations, value of RSD found was 0. 82 %. The proposed method has been used in the determination of content of pyritinol hydrochloride in its tablets, giving results in consistency with the labelled values.

关 键 词：线性扫描极谱法 盐酸吡硫醇 吸附波 

分 类 号：O657.1[理学—分析化学]