Synthesis and bioactivity of N-tert-butyl-N′-acyl-5-methy 1-1,2,3-thiadiazole-4-carbohydrazides  

作　　者：Wu Tao Mao Hui Zhao Zhi Jin Fan Xiao Tian Ji Xue Wen Hua Tatiana Kalinina Yu.Morzherin Yury A.Bakulev Vasiliy 

机构地区：[1]Department of Chemistry,Tianjin University,Tianjin 300072,China [2]State Key Laboratory of Elemento-Organic Chemistry,Nankai University,Tianfin 300071,China [3]The Ural Federal University Named after the First President of Russia B.N.Yeltsin,Yeltsin UrFU 620002,Ekaterinburg,Russia

出　　处：《Chinese Chemical Letters》2012年第11期1233-1236,共4页中国化学快报（英文版）

基　　金：funded in part by the NNSFC(No.20872071);the NSF of Tianjin(No.10JCZDJC17500);the National Key Project for Basic Research(No.2010CB126105);National Key Technology Research and Development Program(Nos.2011BAE06B02 and 2011BAE06B05);the Foundation of Achievements Transformation and Application of Tianjin Agricultural Science and Technology(No.201002250);Tianjin Key Technology Research and Development Program(No.11ZCGYNC00100)

摘　　要：A series of novel N-tert-butyl-N＇-acyl-5-methyl-1,2,3-thiadiazole-4-carbohydrazides were designed and synthesized. Their structures were characterized by melting points, ^1H NMR, IR, ESI-MS, and elemental analysis. The bioassay tests indicated that compound 7o exhibited excellent direct anti-TMV activity and induction activity in vivo at 50μg/mL, which was better than that of Ninamycin and tiadinial. Our studies indicated that 1,2,3-thiadiazole was an active substructure for novel pesticide development.A series of novel N-tert-butyl-N＇-acyl-5-methyl-1,2,3-thiadiazole-4-carbohydrazides were designed and synthesized. Their structures were characterized by melting points, ^1H NMR, IR, ESI-MS, and elemental analysis. The bioassay tests indicated that compound 7o exhibited excellent direct anti-TMV activity and induction activity in vivo at 50μg/mL, which was better than that of Ninamycin and tiadinial. Our studies indicated that 1,2,3-thiadiazole was an active substructure for novel pesticide development.

关 键 词：Antivirus activity Systemic acquired resistance SYNTHESIS 1 2 3-Thiadiazole DIACYLHYDRAZINE 

分 类 号：TQ455.47[化学工程—农药化工] S482.39[农业科学—农药学]