Cytotoxic terpenes from Abies sibirica  

作　　者：Gui Rong Wang Yong Li Li Wei Dong Zhang Xian Wen Yang Wen Cong Liu Ji Ye Zhi Jun Zhu Hong Chen 

机构地区：[1]Department of Phytochemistry,School of Pharmacy,Second Military Medical University,Shanghai 200433,China [2]Department of Pharmacognosy,Jilin Agricultural University,Changchun 130118,China [3]School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Chinese Chemical Letters》2012年第11期1251-1253,共3页中国化学快报（英文版）

基　　金：supported by program NCET Foundation;NSFC(No.30725045);partially supported by Global Research Network for Medicinal Plants(GRNMP);King Saud University,Shanghai Leading Academic Discipline Project(No.B906),FP7- PEOPLE-IRSES-2008(TCMCANCER Project 230232);Key Laboratory of Drug Research for Special Environments,PLA,Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(No.10DZ2251300);the Scientific Foundation of Shanghai China(No.09DZ1975700,09DZ1971500, 10DZ1971700);the Twelfth Five-Year National Science & Technology Support Program(No.2012BAI29B06)

摘　　要：One new and 16 known compounds were isolated from Abies sibirica. Their structures were assigned mainly on the basis of NMR and MS spectroscopic data. In bioassay for anti-proliferative activity against four human tumor cells, compound 7 exhibited selective anti-proliferative activity against COLO-205 tumor cell with an IC50 value of 0.9 μg/mL.One new and 16 known compounds were isolated from Abies sibirica. Their structures were assigned mainly on the basis of NMR and MS spectroscopic data. In bioassay for anti-proliferative activity against four human tumor cells, compound 7 exhibited selective anti-proliferative activity against COLO-205 tumor cell with an IC50 value of 0.9 μg/mL.

关 键 词：Abies sibirica PINACEAE TERPENES TRITERPENE 

分 类 号：Q959.133[生物学—动物学] S791.14[农业科学—林木遗传育种]