An efficient and facile synthesis of N-Cbz-β-aminoalkanesulfonamides  

作　　者：MENG FanHua CHEN Ning XU JiaXi 

机构地区：[1]State Key Laboratory of Chemical Resource Engineering,Department of Organic Chemistry,Faculty of Science,Beijing University of Chemical Technology,Beijing 100029,China

出　　处：《Science China Chemistry》2012年第12期2548-2553,共6页中国科学（化学英文版）

基　　金：the support from the National Natural Science Foundation of China(20973013);Beijing Natural Science Foundation(2092022)

摘　　要：An efficient method for the synthesis of N-Cbz-β-aminoalkanesulfonamides was described.N-Cbz-β-aminoalkanesulfonamides were readily prepared in good yields from a variety of amino alcohols,including optically active ones,via N-Cbz protection with benzyl chloroformate,Mitsunobu esterification reaction with thiolacetic acid,N-chlorosuccinimide oxidation,and ammonolysis process.An efficient method for the synthesis of N-Cbz-β-aminoalkanesulfonamides was described. N-Cbz-β-aminoalkanesulfonamides were readily prepared in good yields from a variety of amino alcohols, including optically active ones, via N-Cbz protection with benzyl chloroformate, Mitsunobu esterification reaction with thiolacetic acid, N-chlorosuccinimide oxidation, and ammonolysis process.

关 键 词：SULFONAMIDES amino alcohols SYNTHESIS Mitsunobu reaction AMMONOLYSIS 

分 类 号：O621.3[理学—有机化学]