基于“症”的2型糖尿病中医证候聚类分析  

Cluster analysis of syndrome differentiation types of type 2 diabetes mellitus based on symptoms

作　　者：周迪夷[1] 赵进喜[1] 牟新[2] 刘文洪[3] 周旦阳[2] 刘颖慧[2] 马国玲[2] 胡永宾[2] 寿成珉[2] 陈家炜[2] 王硕仁[4] 

机构地区：[1]北京中医药大学东直门医院肾病内分泌科,北京100700 [2]杭州市红十字会医院内分泌科,杭州310003 [3]浙江中医药大学生物工程学院,杭州310000 [4]北京中医药大学东直门医院教育部和北京市中医内科学重点实验室,北京100700

出　　处：《中华中医药杂志》2012年第12期3121-3124,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.30801467)~~

摘　　要：目的:探索2型糖尿病中医证候分布规律和方法,为进一步研究该病的病因病机及证候特点提供依据。方法:按照量表的制作方法,制定糖尿病(糖尿病肾病)中医证候问卷,对180例2型糖尿病患者进行了调查,对所得数据进行频数统计和聚类分析。结果:出现频率大于50%的症状条目中,本虚证表现以气虚和阴虚证为主,标实证表现以内热和痰湿为主;进一步对症状条目进行聚类分析,得到2型糖尿病的7个证候类型。结论:2型糖尿病本虚证中,气虚证和阴虚证,阴虚证和阳虚证并见,也有单纯气虚证或单纯阴虚证。标实证中,热证普遍存在,也兼有血瘀证。从症状出发,运用聚类分析进行中医证候研究的方法具有可行性。Objective： To explore distribution regularity and methodology of syndrome differentiation types of type 2 Diabetes Mellitus（T2DM） based on symptoms,and provided evidences to etiology,pathogenesis and syndrome characters.Methods： According to scale making method to design TCM syndrome scale,we launched an investigation on 180 patients with type 2 diabetes and had a frequency and cluster analysis.Results： Among symptom terms with frequencies above 50%,root deficiency syndromes were mostly Qi deficiency and Yin deficiency,superficial repletion mostly internal heat and phlegm-dampness.After having a cluster analysis,7 syndromes were summarized from type 2 diabetes.Conclusion： Among all syndromes,Qi and Yin deficiency or Yin and Yang deficiency existed together,single Qi or Yin deficiency also was found,heat syndrome was universal,sometimes coupling with blood stasis.Based on symptoms,the method appling clustering analysis to study TCM syndrome was feasible.

关 键 词：2型糖尿病 辨证分型 聚类分析 四诊信息 中医证候 症状 

分 类 号：R259[医药卫生—中西医结合]