论“痰”在慢性阻塞性肺疾病发病及治疗中的重要性  

Importance of 'phlegm' in COPD pathogenesis and treatment

作　　者：钟相根[1] 祝小惠[1] 郑子安[1] 潘霏[1] 闻晓婧[1] 

机构地区：[1]北京中医药大学基础医学院,北京100029

出　　处：《中华中医药杂志》2012年第12期3159-3161,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81173314);教育部新世纪优秀人才支持计划(No.NCET-08-0745)~~

摘　　要：痰既是慢性阻塞性肺疾病(COPD)的主要病理产物,又是其重要的致病因素,是COPD迁延不愈不断恶化的关键环节之一。COPD气道黏液高分泌,与中医学"痰"密切相关。气道黏液高分泌是所有COPD病人的重要临床病理特征,亦包括无咳嗽和咯痰症状的COPD病人。传统的COPD发病机制观点需要重新评价。气道黏液高分泌是COPD发病最重要的先兆因素,与肺功能下降、住院率和病死率密切相关,是影响COPD病情进展的独立危险因素。COPD病情恶化的重要形态学基础——小气道黏液潴留,与中医学"宿痰伏肺"的观点不谋而合,故治痰是COPD的重要治疗原则。Phlegm was not only the major pathological product,but also pathogenics factor of COPD,which played a key role in COPD deteriorating.Airway mucus hypersecretion in COPD was related closely to ＇phlegm＇ in TCM.It was clinical pathological feature in all COPD patients,including who didn＇t have the symptoms of cough or cough up phlegm.Traditional views about pathogenic mechanism needed re-evaluation.Airway mucus hypersecretion was principal indication,which was related with lung function,hospitalization rate and death rate and independent risk of COPD deteriorating.Morphological basis of COPD,small airway grume storage,was equivalent with the view of ＇former phlegm hiding lung＇ in TCM.Therefore,resolving phlegm was the significant principle in treating COPD.

关 键 词：痰 黏液高分泌 慢性阻塞性肺疾病 

分 类 号：R563.9[医药卫生—呼吸系统]