异位骨化的治疗新进展  

Recent Development of Heterotopic Ossification Treatment

作　　者：吴江[1] 肖海军[1] 

机构地区：[1]南方医科大学附属奉贤区中心医院骨科,上海201400

出　　处：《医学综述》2012年第22期3808-3811,共4页Medical Recapitulate

摘　　要：异位骨化是一种软组织内的病理性骨生成,可以导致受累关节功能丧失。异位骨化与许多因素有关,如创伤性脑损伤或脊髓损伤、烧伤、创伤、关节成形术及其他手术、细胞因子、遗传因素和围术期使用的药物等。但是,确切的机制仍未阐明。有假说认为,局部或全身因素失衡诱导的造骨原始细胞在HO的病理过程中起作用。常用的治疗异位骨化的方法有非甾体类药物、双磷酸盐、辐射治疗、手术切除等。Heterotopic ossification（HO）is pathologic ectopic bone formation in soft tissue which can lead to joint dysfunction.There are several related factors for HO,such as traumatic brain or spinal cord injuries,burn injuries,trauma,joint arthroplasty and other orthopedic surgical procedures,cytokine,genetic factor and perioperative drugs,while the definite pathogenesis is still unclear.A posited theory is that HO results from the presence of osteoprogenitor cells pathologically induced by an imbalance of local or systemic factors.The prevailing recommendation for management of HO consists of nonsteroidal anti-inflammatory drugs,bisphosphonates,radiotherapy and surgical resection.

关 键 词：异位骨化 治疗 进展 

分 类 号：R683[医药卫生—骨科学] R453[医药卫生—外科学]