Perkin反应合成肉桂酸的工艺研究  

The Research on Synthesis Technology of Cinnamic Acid by Perkin Reaction

作　　者：李海花[1] 张艳丽[1] 张建生[1] 闫顺生[2] 杨艳红[1] 

机构地区：[1]唐山学院环境与化学工程系,河北唐山063000 [2]唐山学院基础教学部,河北唐山063000

出　　处：《唐山学院学报》2012年第6期50-53,共4页Journal of Tangshan University

摘　　要：采用Perkin反应合成肉桂酸,以苯甲醛和乙酸酐为原料,研究了碱性催化剂无水醋酸钾与无水碳酸钾的催化活性,证实无水碳酸钾的催化活性优于无水醋酸钾。进一步以无水碳酸钾为催化剂,设计正交实验,得到合成肉桂酸的最佳工艺参数。研究结果表明:合成肉桂酸的最佳合成条件为苯甲醛与乙酸酐的摩尔比为1∶3,反应时间为90min,苯甲醛与无水碳酸钾的摩尔比为1∶1,在此条件下所合成的肉桂酸样品,产率61.2%,产品纯度达到97%以上。In this paper,cinnamic acid is synthesized by using the Perkin reaction.The catalytic activity of the conventional catalysts such as anhydrous potassium acetate and anhydrous potassium carbonate is analyzed,and the results show that the catalytic activity of anhydrous potassium carbonate is superior to anhydrous potassium acetate.With the orthogonal experiments and anhydrous potassium carbonate as the catalyst,the cinnamic acid is synthesized in the optimum process parameters as follows： benzaldehyde∶ acetic anhydride=1∶3,reaction time 90 min,benzaldehyde∶ potassium carbonate=1∶1 conditions,with 61.2% of the yield and above 97% of the purity.

关 键 词：PERKIN反应 肉桂酸 合成 正交实验 

分 类 号：TQ216[化学工程—有机化工]