上海市部分地区健康人群水痘-带状疱疹病毒抗体水平调查  

Survey of antibody levels to varicella-zoster virus in healthy population in Shanghai

作　　者：杨玉颖[1] 汤素文[1] 刘景壹[2] 李智[1] 陆红梅[3] 陈文花[3] 吴强松[2] 郭翔[1] 李崇山[1] 孙晓冬[1] 许文波[4] 

机构地区：[1]上海市疾病预防控制中心,上海200336 [2]上海市徐汇区疾病预防控制中心 [3]上海市松江区疾病预防控制中心 [4]中国疾病预防控制中心病毒病预防控制所

出　　处：《疾病监测》2012年第11期868-872,共5页Disease Surveillance

基　　金：上海市科学技术委员会科研计划项目(No.10411961700);上海市徐汇区医学科研项目(No.SHXH201114)~~

摘　　要：目的了解上海市部分地区健康人群水痘抗体水平。方法采集1～40岁健康人群血清标本2001份,采用酶联免疫吸附试验定量检测水痘IgG抗体。结果人群血清中水痘抗体阳性率为57.57%,几何平均浓度(Geometricmean concentration,GMC)为171.15 mIU/ml。8个年龄组抗体阳性率及浓度总体上呈随年龄增长而上升的趋势,18岁以下各年龄组的阳性率为41.90%～66.45%、GMC为77.23～269.59 mIU/ml,19～29岁组阳性率为85.12%、GMC为610.06 mIU/ml,30～40岁组阳性率达到96.25%、GMC为953.30 mIU/ml。不同年龄组市区和郊区人群水痘抗体阳性率及浓度差异有统计学意义,郊区1～3岁年龄组阳性率及抗体浓度显著高于市区同年龄儿童。接种过水痘疫苗人群GMC为178.55 mIU/ml,未接种人群GMC为76.74 mIU/ml,二者差异有统计学意义。结论 1～6岁儿童是水痘的易感人群,应该重点关注这一年龄段儿童水痘疫苗接种工作,建议我国能够采取2剂次水痘疫苗的免疫策略。Objective To understand the antibody levels to varicella-zoster virus in healthy population in Shanghai.Methods Totally 2001 serum samples were collected from healthy people aged from 1 to 40 years in some areas of Shanghai to detect varicella IgG antibodies by ELISA.Results The overall positive rate of varicella antibody was 57.57%,the GMC of varicella antibody was 171.15 mIU/ml.In the eight age groups,the positive rate rose with age.In people less 18 years old the positive rates ranged from 41.90% to 66.45%,the GMCs ranged from 77.23 mIU/ml to 269.59 mIU/ml.In age group 19-29 years the positive rate was 85.12% and the GMC was 610.06 mIU/ml.In age group 30-40 years the positive rate of was 96.25% and the GMC was 953.30 mIU/ml.The age specific positive rates and the concentrations of varicella antibody had significant differences between the residents in urban and suburb areas,which were,in age group 1-3 years,dramatically higher in suburb residents than those in urban residents.The GMC of people who received varicella vaccination was 178.55 mIU/ml,while the GMC of those receiving no vaccination was 76.74 mIU/ml,the difference was statistical significant.Conclusion Children aged from 1 to 6 years are susceptible to varicella.The varicella vaccination should be strengthened in this age group and two-dose regimen is recommended.

关 键 词：水痘 抗体水平 几何平均浓度 

分 类 号：R181.3[医药卫生—流行病学]