免疫状态及Th1/Th2型细胞因子在支气管哮喘患儿治疗前后的变化  

Change of immune state and Th1/Th2 cytokines of children with bronchial asthma before and after the treatment

作　　者：钟婕[1] 陈胜利[1] 许博[1] 王琴[1] 高海燕[1] 

机构地区：[1]广东省东莞市厚街医院儿科,广东东莞523945

出　　处：《海南医学院学报》2012年第12期1695-1697,共3页Journal of Hainan Medical University

基　　金：东莞市科技计划医疗卫生类科研一般项目(编号:201210515000210)~~

摘　　要：目的:探讨支气管哮喘患儿治疗前后免疫状态及Th1/Th2型细胞因子的变化规律。方法:选取2012年5月～2013年11月于本院进行治疗的50例支气管哮喘患儿为观察组,同期体检的50名健康儿童为对照组,将观察组治疗前及治疗不同时间段和对照组的外周血T淋巴细胞亚群、红细胞免疫指标及Th1/Th2型细胞因子进行比较。结果:治疗前观察组的CD3+、CD4+及CD4/CD8均低于对照组,CD8+高于对照组,RBC-C3bR及FEER均低于对照组,RBC-ICR及FEIR均高于对照组,IFN-γ、IL-2及IL-10均低于对照组,IL-4、IL-5及IL-13高于对照组,而治疗后不同时间段上述指标呈现持续改善,P均<0.05,均有显著性差异。结论:支气管哮喘患儿治疗后免疫状态及Th1/Th2型细胞因子呈现持续改善的趋势。Objective： To study the variation of immune state and Th1/Th2 cytokines of children with bronchial asthma before and after the treatment.Methods：A total of 50 children with bronchial asthma treated in our hospital from May 2012 to November 2013 were selected as observation group,and 50 healthy children were selected as control group at the same time,then the peripheral blood T lymphocyte subsets,erythrocyte immune indexes and Th1/Th2 cytokines of observation group before and after the treatment at different times and observation group were compared.Results：The CD3＋,CD4＋ and CD4/CD8 of observation group before the treatment were all lower than those of control group,CD8＋ was higher than that of control group,RBC-C3bR and FEER were lower than those of control group,RBC-ICR and FEIR were higher than those of control group,IFN-γ、IL-2 and IL-10 were lower than those of control group,IL-4,IL-5 and IL-13 were higher than those of control group,while those items of observation group after the treatment at different times showed a continuous-improvement（all P0.05）.Conclusions：After the treatment,the immune state and Th1/Th2 cytokines of children with bronchial asthma shows a continuous-improvement.

关 键 词：支气管哮喘 免疫状态 TH1 TH2型细胞因子 变化规律 

分 类 号：R5[医药卫生—内科学]