道地与非道地黄芩的药效比较研究  

Comparative study on anti-inflammatory and antipyretic effects between Dao-di herb and non Dao-di herb of Huangqin

作　　者：吴再旺[1] 王喆明[1] 卢月[1] 王丹[2] 钱瑞琴[1] 尚明英[3] 王璇[2] 蔡少青[3] 

机构地区：[1]北京大学基础医学院中西医结合教研室,北京100191 [2]北京大学药学院化学生物学系,北京100191 [3]北京大学药学院天然药物学系,北京100191

出　　处：《中国中药杂志》2012年第23期3628-3632,共5页China Journal of Chinese Materia Medica

基　　金：国家重点基础研究发展计划"973"项目(2006CB504707)

摘　　要：目的:比较道地与非道地黄芩的解热和抗炎作用,为对道地药材的药性特征认识和临床应用提供实验依据。方法:采用酵母致小鼠发热模型、二甲苯致小鼠耳廓肿胀实验评价不同产地黄芩的解热、抗炎作用。结果:10个产地的道地与非道地黄芩对酵母致热模型体温均有抑制作用,道地黄芩对体温的抑制率在61%～53%,非道地黄芩在53%～43%,其中6个道地产区黄芩对体温的抑制率均优于4个非道地产区。10个产地的道地与非道地黄芩均有抑制鼠耳肿胀作用,道地黄芩的肿胀抑制率在73%～54%,非道地黄芩的肿胀抑制率在53%～34%,其中6个道地产区黄芩的肿胀抑制率均优于4个非道地产区。道地性排序分析表明,古代道地与现代道地黄芩的解热、抗炎作用均优于非道地黄芩,现代道地黄芩解热、抗炎作用强于古代道地黄芩。结论:不同产地黄芩均有解热、抗炎的作用,但作用强度不同,道地产区黄芩优于非道地产区黄芩,表明黄芩具有一定的道地性。Objective： To do some comparative study on anti-inflammatory and antipyretic effects between the Dao-di herb and non Dao-di herb of Huangqin （ the roots of Scutellaria baicalensis） and provide thinking and evidence for study on geoherbalism and clinical usage of Huangqin. Method： The anti-inflammatory action was assessed by auricular swelling induced by dimethylbenzene in mice and the antipyretic action was monitored by dried yeast-induced mice fever. Result： All samples of both Dao-di and non Dao-di herbs of Huangqin showed antipyretic effect. The Dao-di Huangqin samples showed antipyretic effect between 61% to 53%, whereas the non Dao-di Huangqin samples between 53% to 43%. Six Dao-di Huangqin samples showed better antipyretic effect than four non Dao-di Huangqin samples. All samples of both Dao-di and non Dao-di Huangqin showed anti-inflammatory effect. Dao-di Huangqin showed anti-inflammatory effect between 73% to 54%, whereas non dao-di Huangqin between 53% to 34%. Six Dao-di Huangqin showed better anti-inflammatory effect than four non Dao-di Huangqin. In totality, results from analysis of geoherbalism showed that geoherbal production areas of Huangqin had better effect than that of the non geoherbal production areas in anti-inflammatory and anti- pyretic effects. Conclusion ： Both the Dao-di and non Dao-di Huangqin have effects of anti-inflammatory and antipyretic to a certain extent, but the efficacy of the Dao-di Huangqin surpass the non Dao-di Huangqin.

关 键 词：黄芩 道地性 抗炎 解热 

分 类 号：R285[医药卫生—中药学]