丙泊酚麻醉对胆管手术患者PMN凋亡及IL-10的影响  

Effect of Propofol on PMN Apoptosis and Interleukin-10 in Patients with Biliary Duct Surgery

作　　者：李海东[1] 

机构地区：[1]北京市平谷区医院药剂科,北京101200

出　　处：《中国医药导刊》2012年第11期1928-1929,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨丙泊酚麻醉对胆管手术患者中性粒细胞(PMN)凋亡及白细胞介素-10(IL-10)的影响。方法:选择2009年1月～2010年12月我院收治的ASAⅠ～Ⅱ级择期行胆管手术患者60例,按随机数字表法分为丙泊酚组(30例)与七氟醚组(30例),在术前(T0)、手术开始即刻(T1)、手术开始2h(T2)、手术开始12h(T3)、手术开始24h(T4)及手术开始48h(T5)时取肘静脉血检测PMN凋亡率及IL-10水平。随机选取同期在我院门诊健康体检正常者30例为对照组。结果:术前丙泊酚组与七氟醚组PMN凋亡率均明显低于对照组(P<0.05),IL-10水平均明显高于对照组(P<0.05)。丙泊酚组在T2、T3、T4时点的PMN凋亡率及IL-10水平均明显高于七氟醚组(P<0.05)。结论:丙泊酚麻醉能明显抑制胆管手术患者PMN凋亡,升高IL-10水平。Objective：To investigate the effects of propofol on PMN apoptosis and interleukin-10（IL-10） in patients with biliary duct surgery.Methods：A total of sixty ASA Ⅰ～Ⅱ patients scheduled for biliary duct surgery in our hospital from January 2009 to December 2010 were randomly divided into propofol group（30 cases） and Sevoflurane group（30 cases）.Peripheral venous blood samples were obtained immediately at the time of before surgery（T0）,surgery beginning（T1）,2h after surgery beginning（T2）,12h after surgery beginning（T3）,4h after surgery beginning（T4） and 48h after surgery beginning（T5）,to detect the PMN apoptosis rate and IL-10 levels.Over the same period randomly selected 30 cases healthy people as the control group.Results：PMN apoptosis rates were significantly lower than the control group before the surgery in propofol group and sevoflurane group（P0.05）,the IL-10 levels were all significantly higher than the control group before the surgery（P0.05）;the PMN apoptosis rates and IL-10 levels in Propofol group at the point of T2,T3,T4 were significantly higher than that of sevoflurane group（P0.05）.Conclusion：Propofol can obviously inhibit the PMN apoptosis rate and increased.IL-10 levels in patients with biliary duct surgery.

关 键 词：丙泊酚 胆管手术 PMN IL-10 

分 类 号：R614.2[医药卫生—麻醉学]