泮托拉唑预防危重症患者并发应激性溃疡的临床观察  

Clinical study on pantoprazole to prevent the occurrence of stress ulcer in critical patients

作　　者：苑振云[1] 姜相明[1] 杨秀芬[1] 李庆威[1] 苏冠丽[1] 李斌[1] 

机构地区：[1]河北医科大学第一医院急诊科,河北石家庄050031

出　　处：《中国医院药学杂志》2012年第23期1900-1902,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:观察泮托拉唑对危重症患者预防应激性溃疡的效果。方法:对2008年10月-2011年6月收治的115例危重症患者随机分为研究组(58例)和对照组(57例),对2组患者均给予常规的抢救,另外对研究组患者及时给予泮托拉唑钠治疗,对照组患者给予西咪替丁治疗。观察2组患者肝肾功能、应激性溃疡出血的发生率及死亡率。结果:2组患者治疗前后肝、肾功能差异均无统计学意义(P>0.05)。研究组应激性溃疡的发生率明显低于对照组(P<0.01),死亡率亦明显低于对照组(P<0.05)。结论:泮托拉唑能有效预防危重症患者应激性溃疡的发生,并有助于降低死亡率。OBJECTIVE To observe the clinical effects of pantoprazole to prevent the occurrence of stress ulcer in critical pa tients. METHODS 115 cases of critical patients treated in our emergency department from October, 2008 to June, 2011 were randomly divided into the experimental group （58 cases） who were trea：ted with pantoprazole on the base of conventional salvage and control group （57 cases） who were treated with cimetidine on the base of conventional salvage. The liver and renal func tions and the incidence of hemorrhage of stress ulcer and mortality were observed between two groups. RESULTS There were no statistic differences of liver function and renal function pre-and post-treatment between two groups（P〉0. 05）. The inci dence of hemorrhage of stress ulcer in the experimental group was significantly lower than tbat in the control group （P〈0. （11） and the mortality was also significantly lower than that in the control group （P〈0. 05）. CONCLUSION Panloprazole can ef fectively prevent the occurrence of stress ulcer and heln to reduce mortality in critical patients.

关 键 词：泮托拉唑 应激性溃疡 预防 危重症 

分 类 号：R969[医药卫生—药理学]