稳定性心绞痛患者血糖水平与循环微小RNA-92a表达关系的研究  

Relation between blood glucose level and circulating microRNA-92a expression in patients with stable angina pectoris

作　　者：王虹[1] 刘伶[1] 龚国平[1] 李友琼[2] 陆红梅[1] 林英忠[1] 

机构地区：[1]广西壮族自治区人民医院心内科,南宁530021 [2]广西壮族自治区人民医院中心实验室,南宁530021

出　　处：《中华老年心脑血管病杂志》2012年第12期1252-1255,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：广西医疗卫生重点课题(2010026)

摘　　要：目的探讨稳定性心绞痛(SAP)患者循环微小RNA-92a(microRNA-92a,miR-92a)表达与血糖的关系。方法将93例SAP患者分为A组:降糖治疗+空腹血糖(FPG)<7.0 mmol/L 18例,B组:降糖治疗+FPG≥7.0 mmol/L8例,C组:非降糖治疗+FPG<7.0 mmol/L 61例,D组:非降糖治疗+FPG≥7.0 mmol/L 6例。比较4组患者血糖水平与循环miR-92a表达的关系。结果 SAP患者合并2型糖尿病发病率为34.4%,降糖治疗后,仍有30.8%FPG≥7.0 mmol/L。A组与B组miR-92a是否>-0.1或>0.5水平的OR值分别为2.67或0.17,C组与D组OR值分别为0.36、0.48。A组miR-92a>-0.1的患者为88.9%,显著高于C组的41.0%(P<0.01)。B组miR-92a>0.5的患者为75.0%,高于A组的33.3%(P>0.05)。结论单纯测定FPG诊断2型糖尿病漏诊率高。循环miR-92a有助于FPG<7.0 mmol/L的SAP合并2型糖尿病的诊断及疗效评价。Objective To study the relation between blood glucose level and circulating microRNA-92a expression in patients with stable angina pectoris （SAP）. Methods Ninety-three SAP patients were divided into hypoglycemic treatment（HT） ＋ fasting plasma glucose（FPG）〈7.0 mmol/L group（group A,n=18）, HT＋FPG〈7.0 mmol/L group（group B,n=8）,non-HT＋FPG〈7.0 mmol/L group（group C,n=61）,and non-HT＋FPG〈7.0 mmol/L group（group D,n=6）. Relation between blood glucose level and circulating microRNA-92a expression was compared in 4 groups. Results The incidence of type 2 diabetes mellitus（DM） was 34.4% in SAP patients. The FPG level was 〈7.0 mmol/L in 30.8% of the patients after HT. The OR value was 2.67 and 0. 17 respectively in groups A and B,and 0.36 and 0.48 respectively in groups C and D. The pro- portion of patients in group A with their microRNA-92a expression level up-regulated was significantly higher than that of those in group C（88.9% vs 41.0%,P〈0.01）. The proportion of patients in group B with their microRNA-92a expression level up-regulated（〉0.5） was significantly higher than that 0f those in group A（75.0% vs 33.3 % P〉0.05）. Conclusion The missed diagnosis rate of type 2 DM is high according to the simple FPG level. MicroRNA-92a expression level contributes to the diagnosis of SAP accompanying type 2 DM and to the assessment of its thera- peutic effect when the FPG level is %7.0 mmol/L.

关 键 词：心绞痛 血糖 糖尿病 2型 微RNAS 基因表达 降血糖药 内皮细胞 

分 类 号：R587.1[医药卫生—内分泌]