一种多通道微流控芯片压力检测方法研究  

Study on a multi-channel micro fluid chip pressure measurement method based on laminar flow distribution

作　　者：杨国清[1] 廖彦剑[1,2] 杨军[1,2] 陈礼[1] 郑小林[1,2] 胡宁[1] 

机构地区：[1]重庆大学生物工程学院,重庆400044 [2]生物流变科学与技术教育部重点实验室,重庆400044

出　　处：《仪器仪表学报》2012年第11期2546-2551,共6页Chinese Journal of Scientific Instrument

基　　金：国家自然科学基金(81101168;81071278);重庆市科委计划攻关项目(cstc2009ab5202;cstc2011bb5050);中央高校基本科研业务费项目(CDJZR10230013);重庆大学大型仪器设备开放基金(2011063039)资助项目

摘　　要：针对微流控芯片中的流路压力,特别是多通道的压力测量问题,提出了一种利用微尺度层流结合显微图像处理进行多通道压力(流速)测量的方法,并以双路通道情况为例,设计并制作了一种基于层流的多通道压力检测芯片。主要研究内容包括微尺度层流条件下压力(流速)测量方法的建立、多通道压力测压芯片的设计和制作、对该芯片模型的仿真分析和利用显微图像处理获得实验数据几个方面。最终,通过设计验证实验得到的数据与仿真结果的对比,验证了方法的可行性。Aiming at the flow pressure in micro fluidic chip, especially the multi-channel pressure measurement problem, this paper provides a micro fluidic chip multi-channel pressure measurement method based on laminar flow distribution and microscopic image processing method. Taking the two channel case as an example, a multi-channel pressure measurement chip was designed and fabricated. This paper mainly focuses on the formula derivation of pressure measurement, design and fabrication of multi-channel micro fluidic chip, model simulation and analysis, and acquiring experiment data with microscope image processing. Furthermore, the data obtained from design verification experiment ware compared with simulation result, which proves the feasibility of the proposed method.

关 键 词：压力检测 微尺度层流 显微图像 

分 类 号：R318.6[医药卫生—生物医学工程]