黏球菌189B05的次级代谢产物研究  

Secondary Metabolites Produced by Myxococcus sp. 189B05

作　　者：刘新利[1] 李瑶瑶[2] 许晓坤[1] 鲁春华[2] 

机构地区：[1]山东轻工业学院教育部生物化学重点实验室山东省微生物工程重点实验室,济南250353 [2]山东大学药学院教育部生物化学重点实验室,济南250012

出　　处：《中国药学杂志》2012年第23期1883-1885,共3页Chinese Pharmaceutical Journal

基　　金：“863”目标导向课题(2006AA02Z171);山东大学自主创新基金(2010TB016)

摘　　要：目的对黏球菌(Myxococcus sp.)189B05大罐发酵吸附树脂提取物的化学成分进行研究。方法采用Sephadex LH-20和硅胶等色谱柱色谱进行分离纯化,用波谱技术鉴定化合物的结构。结果从70 L发酵提取物中分离得到5个化合物,分别为quinolin-4-ylmethanol(1),myxothiazol(2),4-quinolinecarboxaldehyde oxime(3),N-(2-phenylethyl)acetamide(4),N-acetyltyra-mine(5)。结论化合物1～5均为首次从该菌株中分离得到。OBJECTIVE To study the chemical constituents ofMyxococcus sp. 189B05 isolated from crop land soil sample col- lected in Shandong province. METHODS The constituents were isolated and purified by Sephadex LH -20 and silica columns and their structures were identified by NMR and ESIMS techniques. RESULTS Five compounds were isolated and identified as quinolin- 4-ylmethanol（ 1 ）, myxothiazol （2） ,4-quinolinecarboxaldehyde oxime （ 3 ）, N- （2-phenylethyl） acetamide （4）, N-acetyhyramine （ 5 ）, re- spectively. CONCLUSION Compounds 1 -5 were obtained from the strain for the first time.

关 键 词：黏球菌189B05 柱色谱 结构鉴定 MYXOTHIAZOL 

分 类 号：R284[医药卫生—中药学]