IGF-1、IGFBP-3在2型糖尿病周围神经病变诊断中意义的研究  

The role of IGF-1 and IGFBP-3 in diagnosis of type 2 diabetic peripheral neuropathy

作　　者：侯秀竹[1] 张国军[1] 康熙雄[1] 

机构地区：[1]首都医科大学附属北京天坛医院检验科,北京100050

出　　处：《中国医药生物技术》2012年第6期426-429,共4页Chinese Medicinal Biotechnology

基　　金：国家高技术研究发展计划(863计划)(2011AA02A103)

摘　　要：目的探讨外周血IGF-1和IGFBP-3在2型糖尿病周围神经病诊断中的意义。方法研究对象分为2型糖尿病周围神经病组、2型糖尿病无周围神经病组和健康人群组3组,以化学发光法检测血清中IGF-1和IGFBP-3水平。结果 IGF-1和IGFBP-3水平在周围神经病组[IGF-1:(132.65±50.78)ng/ml;IGFBP-3:(3.43±1.05)μg/ml]明显低于无周围神经病组[IGF-1:(160.25±66.13)ng/ml;IGFBP-3:(4.37±1.35)μg/ml)]和健康对照组[IGF-1:(174.95±64.38)ng/ml;IGFBP-3:(4.75±3.39)μg/ml](P<0.05),而后两组间无统计学差异(P>0.05)。结论 IGF-1和IGFBP-3水平减少与2型糖尿病周围神经病的发生相关,对两者的监测有利于2型糖尿病周围神经病的诊断。Objective To investigate the significance of insulin-like growth factor I （IGF-1） and I insulin-like growth factor binding protein 3 （GFBP-3） in diagnosis of type 2 diabetic peripheral neuropathy. Methods By means of chemiluminescent assay, we detected the content of IGF-1 and IGFBP-3 in sera of experiment subjects. The experimental subjects were divided into three groups, including type 2 diabetic peripheral neuropathy group （DPN group）, type 2 diabetes meUitus without peripheral neuropathy group （DM group） and health group. Results The DPN group had significantly lower levels of IGF-1 and IGFBP-3 [IGF-1： （132.65 ± 50.78） ng/ml; IGFBP-3：（3.43 ± 1.05） μg/ml] compared to either DM group [IGF- 1： （160.25 ± 66.13） ng/ml; IGFBP-3：（4.37 ± 1.35） μg/ml] or health group [IGF- 1： （174.95 ± 64.38） ng/ml; IGFBP-3：（4.75 ± 3.39）μg/ml] （P 〈 0.05）. No significant difference was found between DM group and health group （P 〉 0.05）. Conclusion Decreased levels of IGF-1 and IGFBP-3 in diabetic patients play a role in the occurrence of peripheral neuropathy. It will be helpful to monitor IGF-1 and IGFBP3 levels in the diagnosis of this disease.

关 键 词：糖尿病 2型 周围神经系统疾病 胰岛素样生长因子I 胰岛素样生长因子结合蛋白质3 

分 类 号：R587.2[医药卫生—内分泌]