体内三唑仑及其主要代谢物检验方法研究  

STUDY ON DETERMINATION OF TRIAZOLAM AND IT'S MAJOR METABOLITE IN BIOLOGICAL SAMPLE

作　　者：戴维列[1] 邢若葵[1] 黎乾[1] 王松才[1] 徐淑云[1] 张小婷[1] 陈月梅[1] 

机构地区：[1]广州市刑事科学技术研究所,510030

出　　处：《刑事技术》2000年第2期10-13,共4页Forensic Science and Technology

摘　　要：使用内部质量控制的酶水解、液-液萃取法提取,GC-ECD及GC-MS/MS检测法对体内组织、体液的三唑仑及α-羟基三唑仑进行检测,能够同时定量检测出其他方法难于检测的α-羟基三唑仑和三唑仑成分.同时,通过对人体及动物进行实验,初步确定了三唑仑及α-羟基三唑仑在人体中反动物体内的代谢和动物体内的分布情况.该法具有方法简便、灵敏度高、重现性好、线性范围广、回收率高的特点,经办案实践,证实能够满足实际办案工作的需要.This paper describes an internal standard method of enzymatic hydrolysis, liquid - liquid extraction, GC -ECD and GC -MS/MS analysis to detect triazolam and its major metabolite (a - OH triazolam) in tissue and body fluid. By using this method, the distribution and metabolisability of triazolam andα- OH triazolam in human and animal body have been dectected via human and animal test. This method is simple, sensitive and repeatable. It can be used in case work.

关 键 词：三唑仑 Α-羟基三唑仑 检验 体内分布 法医检验 

分 类 号：D919.2[医药卫生—法医学]