Pathways related to mitochondrial dysfunction in cartilage of endemic osteoarthritis patients in China  

作　　者：LI ChunYan WANG WeiZhuo GUO Xlong ZHANG Feng MA WeiJuan ZHANG YinGang LI YouFen BAI YiDong LAMMI Mikko J 

机构地区：[1]Faculty of Public Health, Medical College of Xi'an Jiaotong University, Key Laboratory of Environment and Gene Related Diseases of Min- istry of Education, Key Laboratory of Trace elements and Endemic Diseases of Ministry of Health, Xi'an 710061, China [2]1nstitute of Health Education of Xi'an, Xi'an 710004, China [3]Department of Orthopedics Surgery, Second Hospital, Xi'an Jiaotong University, Xi'an 710004, China [4]Department of Orthopedics Surgery, First Hospital, Xi'an Jiaotong University, Xi'an 710061, China [5]School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China [6]Department of Cellular and Structural Biology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229, USA [7]Department of Anatomy, Institute of Biomedicine, University of Kuopio, Kuopio, F1N-70211, Finland

出　　处：《Science China(Life Sciences)》2012年第12期1057-1063,共7页中国科学（生命科学英文版）

基　　金：supported in part by the National Natural Science Foundation of China (Grant No. 30972556);the Key Scientific and Technological Innovation Special Projects of Shaanxi "13115" of China (Grant No. 2009ZDKG-79);the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20090201110049)

摘　　要：In this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.In this paper, we present the first evidence of differences in the mitochondria-related gene expression profiles of adult articular cartilage derived from patients with Kashin-Beck disease and normal controls. The expression of 705 mitochondria-related genes was analyzed by mitochondria-related gene expression analysis and ingenuity pathways analysis. Mitochondria-related gene expression analysis identified 9 up-regulated genes in Kashin-Beck disease based on their average expression ratio. Three canonical pathways involved in oxidative phosphorylation, apoptosis signaling and pyruvate metabolism were identified, which indicate the involvement of mitochondrial dysfunction in the pathogenesis of Kashin-Beck disease.

关 键 词：Kashin-Beck disease MICROARRAY mitochondrial dysfunction IPA analysis 

分 类 号：Q954.657[生物学—动物学] S858.28[农业科学—临床兽医学]