芒果苷磷脂复合物自微乳给药系统的制备及其体外评价  

Study on Prescription of Self-microemulsifying Drug Delivery System of Mangiferin Phospholipid Complex

作　　者：轩肖玉[1] 王亚静[1] 田慧[1] 皮佳鑫[1] 孙士真[1] 张伟玲[1] 

机构地区：[1]天津中医药大学/天津市现代中药重点实验室-省部共建国家重点实验室培育基地,天津300193

出　　处：《中药材》2012年第9期1508-1511,共4页Journal of Chinese Medicinal Materials

基　　金：天津市高等学校科技发展基金计划项目(20100211)

摘　　要：目的:研究芒果苷磷脂复合物自微乳给药系统,探求其最佳处方配比,来提高芒果苷的溶出度及生物利用度。方法:通过对油相、乳化剂、助乳化剂的选择和配比优化,结合三元相图,以乳化速度、粒径和电位为指标进行综合评价,确定最佳处方。结果:芒果苷磷脂复合物自微乳的最佳处方比例为肉豆蔻酸异丙酯:聚氧乙烯(35)蓖麻油:辛酸癸酸聚乙二醇甘油酯=2∶4.8∶3.2。结论:按照最佳处方制备的芒果苷磷脂复合物自微乳释药系统可明显改善芒果苷的溶出情况。Objective：To study formulation of self-microemulsifying drug delivery system （SMEDDS） of Mangiferin Phospholipid Complex and improve dissolution and bioavailability of Mangiferin. Methods： Ternary phase diagram was applied to optimize the pre- scription of self-microemulsifying drug delivery system of Mangiferin Phospholipid Complex, and the best recipe was selected by compre- hensive evaluation of the speed of microemulsifying, microemulsion size and electric potential. Results ： The optimum formulation of SMEDDS was composed of IPM-Cremphor EL35-1abrasol = 2： 4. 8： 3.2. Conclusion： Self-microemulsifying drug delivery system of Mangiferin Phospholipid Complex can effectively improve the dissolution of Mangiferin.

关 键 词：芒果苷磷脂复合物 自微乳给药系统 三元相图 溶出度 

分 类 号：R286.1[医药卫生—中药学]