小儿隐睾症患者手术后血清IL-6、IL-8和VEGF检测及其临床意义  

Clinical Significance of Determination of Changes of Serum IL-6,IL-8 and VEGF Levels After Operation in Children with Cryptorchism

作　　者：李延林[1] 朱洪波[1] 苗祥[1] 王凯[1] 李强[1] 

机构地区：[1]连云港市第一人民医院东方医院外科,222042

出　　处：《放射免疫学杂志》2012年第6期615-616,共2页Journal of Radioimmanology

摘　　要：目的:探讨经受手术的小儿隐睾症患儿血清IL-6、IL-8和VEGF水平的变化及临床意义。方法:应用放射免疫分析和酶联法测定31例小儿隐睾症患儿血清IL-6、IL-8和VEGF的含量,并与35名正常健康儿作比较。结果:小儿隐睾症患儿在手术治疗前血清IL-6、IL-8和VEGF水平非常显著地高于正常儿组(P<0.01);经手术治疗3个月后则与正常儿组比较无显著性差异(P>0.05)。结论:小儿隐睾症患儿血清IL-6、IL-8及VEGF水平较高,但经手术后下降,该症的发生、发展与血清IL-6、IL-8和VEGF水平密切相关。Objective To explore the significance of changes of serum IL-6,IL-8 and VEGF levels after operation in children with cryptorchism.Methods Serum IL-6,IL-8（with RIA）,serum VEGF（with ELISA） levels were determined in 31 pediatric patients with cryptorchism both before and after operation as well as in 35 normal controls.Results Before operation serum IL-6,IL-8 and VEGF levels in the patients were significantly higher than those in controls（P0.01）.3 months after operation,the levels were no significant difference from those in controls（P0.05）.Conclusion Serum IL-6,IL-8 and VEGF levels were high in children with cryptochism and dropped after operation,which is closely related with the genesis and progress of cryptorchism in children.

关 键 词：小儿隐睾症 白细胞介素-6 白细胞介素-8 血管内皮生长因子 

分 类 号：R581.1[医药卫生—内分泌]