急性脑出血患者血浆S100B浓度和CT表现的相关性分析  

Correlative Analysis Between Plasma S100B Concentration and Computed Tomographic Manifestations in Patients with Acute Intracerebral Hemorrhage

作　　者：俞一歆[1] 陈文辉[1] 赖旭锋[1] 

机构地区：[1]杭州市第一人民医院放射科,310006

出　　处：《放射免疫学杂志》2012年第6期671-673,共3页Journal of Radioimmanology

摘　　要：目的:探讨急性脑出血患者血浆S100B浓度与CT表现的关系。方法:收集急性基底节区脑出血患者和体检健康者各110例,采用ELISA测定血浆S100B浓度,分析急性脑出血患者血浆S100B浓度的变化及与CT表现的关系。结果:脑出血患者血浆S100B浓度(242.6±112.7)pg/ml较体检健康者(54.2±15.3)pg/ml显著升高(P<0.001)。血浆S100B浓度与血肿体积呈显著相关性(P<0.001)。脑室出血患者血浆S100B浓度显著高于非脑室出血患者(P<0.05)。结论:急性脑出血患者血浆S100B浓度与血肿体积和脑室出血呈显著相关,可以作为一个标志物并可用于反映脑出血的严重程度。Objective This study aimed to investigate the correlation between computed tomographic manifestations and plasma S100B concentration in patients with acute intracerebral hemorrhage.Methods Plasma S100B concentration in one hundred and ten patients with acute basal ganglia hemorrhage and 110 healthy controls were measured using ELISA.The change of plasma S100B level and its correlation with computed tomographic manifestation was analyzed statistically.Results Plasma S100B level was significantly higher in patients with acute intracerebral hemorrhage than in healthy controls（242.6±112.7 pg/ml vs.54.2±15.3 pg/ml;P0.001）.Plasma S100B level was markedly associated with hematoma volumes（P0.001）.Plasma S100B level in patients with intraventricular hemorrhage was obviously higher in patients without intraventricular hemorrhage（P0.05）.Conclusion Plasma S100B concentration are highly correlated with hematoma volumes and intraventricular hemorrhage,this may serve as a marker and also a reflection of disease severity.

关 键 词：急性脑出血 电子计算机体层摄影术 S100B 

分 类 号：R473.5[医药卫生—护理学]