咽舒喷雾剂组方合理性验证研究  

Study on the rationality verification of combination prescription of throat spray

作　　者：崔清华[1] 张雷明[2] 薛云丽[3] 田景振[1] 

机构地区：[1]山东中医药大学,山东济南250335 [2]烟台大学,山东烟台254000 [3]南京绿叶思科药业有限公司,江苏南京210061

出　　处：《齐鲁药事》2012年第11期621-622,共2页qilu pharmaceutical affairs

基　　金：国家"重大新药创制"科技重大专项(2010ZX09102-207)

摘　　要：目的采用药效学和有效组分含量为指标,对咽舒喷雾剂进行组方合理性分析。方法简单拆方法考察不同药材组合提取液中总黄酮和总生物碱含量,用二甲苯致小鼠耳廓肿胀试验,比较其抗炎消肿效果。结果综合总有效组分含量和药效学结果,原处方为最佳处方。结论咽舒喷雾剂组方合理、药效显著,具有较高的开发价值。Objective To analyze the rationality of combination prescription of throat spray, using pharmacodynamic and content of effective component as indices. Methods To observe the contents of total flavonoids and alkaloids in extracts of different drug combination by simple split method. The anti - inflammatory and detumescence effects were compared by auricle swelling test induced by xylene in mice. Results According to the content of total effective components and pharmacodynamic result ~ the original prescription was the optimal prescription. Conclusion The combination prescription of throat spray was reasonable and had significant pharmacodynamie effect with high development value.

关 键 词：咽舒喷雾剂 组方合理性 简单拆方 抗炎 二甲苯 

分 类 号：R289.5[医药卫生—方剂学]