发泡疗法对膝骨性关节炎血清P物质的影响  

Effect of Blistering Therapy on Substanee P in Knee Osteoarthritis

作　　者：张桂燕[1] 余伟吉[1] 蒋顺琓 麦庆春[1] 陈大宇[1] 陈立[1] 马笃军[2] 

机构地区：[1]深圳市中医院,广东深圳518033 [2]湖南中医药大学,湖南长沙4100072

出　　处：《中医药导报》2012年第11期17-19,22,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：深圳市科技局计划项目课题(201003190)

摘　　要：目的:比较发泡治疗与伤湿止痛膏治疗膝骨性关节炎对血清P物质的影响,探讨发泡疗法作用机理。方法:用前瞻性研究方法,将61例膝骨性关节炎患者随机分为治疗组31例和对照组30例,治疗组给予发泡疗法治疗,对照组给予伤湿止痛膏治疗。治疗前、治疗后第15天检测血清P物质水平,评价疼痛、压痛评分。结果:治疗组治疗前血清P物质含量(4.52±2.26)nmol/L,治疗后第15天为(1.05±0.93)nmol/L,对照组治疗前血清P物质含量(4.36±2.94)nmol/L,治疗后第15天为(2.79±1.57)nmol/L,治疗组与对照组血清P物质水平在治疗前、治疗后第15天自身对照、组间对照,差异有统计学意义(P<0.01);治疗组与对照组疼痛、压痛评分在治疗前、治疗后第15天自身对照、组间对照,差异均有统计学意义(P<0.01)。结论:发泡疗法治疗膝骨性关节炎能显著降低血清P物质、改善关节疼痛、压痛;P物质是发泡疗法治疗膝骨性关节炎过程中的重要靶点分子之一。Objective： To compare the affect of serum substance P by Blistering Therapy and Shangshi Zhitong plaster and explore the mechanism of Blistering Therapy. Methods： With the prospective study method, 61 Patients were randomly divided into treatment group（31 cases） and control group（30 cases）; patient in the treatment group were treated by Blistering Therapy, and the patients in the control group were treated with Shangshi Zhitong piaster. The levels of Serum substance P, the weighted tolal scores of pain and tenderness were invested before treatment and after treatment of 15 days. Results： The levels of Serum sub- stance P in the treatment group was（4.52＋2.26）nmol/L before the therapy and（1.05-＋0.93）nmol/L after treatment of 15 days; The lev- els of Serum substance P in the control group were（4.36_＋2.94）nmol/L and（2.79＋l.57）nmol/L respectively. Compared with pre-post treatment in the levels of Serum substance P, there was statistical difference both in two groups（P〈O.01）; the levels of Serum sub- stance P in the treatment group after treatment of 15 days was lower than that of control group（P〈0.01）; Compared with pre-post treatment in the pain and tenderness, there was statistical difference both in two groups（P〈0.01）; the levels of pain and tenderness in the treatment group after treatment of 15 days were lower than that of control group（P〈0.01）.Conclusion： The Blistering Therapy can significantly reduce the level of serum substance P and improve joint pain, tenderness and own worthy of clinical use; sub- stance P is the important target molecule in the process of Blistering Therapy.

关 键 词：发泡疗法 膝骨性关节炎 P物质 神经肽 

分 类 号：R255.6[医药卫生—中医内科学]