运用异病同治法治疗S-COPD和支气管哮喘慢性持续期患者的生存质量分析  

Life Quality Analysis on Patients with S-COPD or Bronchial Asthma in Chronic Persistent Period Treated by Method of "Treating Different Diseases with Same Therapy"

作　　者：杨璐[1,2] 宋芊[1,2] 阎玥[1,2] 孙瑞华[2] 张玲[1,2] 李四维[1,2] 李友林[2] 

机构地区：[1]北京中医药大学,北京100029 [2]中日友好医院,北京100029

出　　处：《上海中医药大学学报》2012年第6期38-41,共4页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药行业科研专项项目(7-21)

摘　　要：目的:探索同一方药对慢性阻塞性肺病稳定期(S-COPD)与支气管哮喘慢性持续期患者生存质量的影响。方法:采用多中心、分段随机分组、平行对照(1∶1)、双盲的临床试验研究设计,将276例S-COPD和支气管哮喘慢性持续期患者随机分为治疗组和对照组,每组138例。治疗组给予西医常规治疗+中药汤剂,对照组给予西医常规治疗+中药安慰剂,疗程为6周。采用圣.乔治呼吸问卷(SGRQ)对所有患者的生存质量进行评价。结果:①治疗后,两组患者的SGRQ各项评分及总分较治疗前均显著降低(P<0.01),且治疗组患者的呼吸症状、疾病影响评分和总分较对照组降低更加显著(P<0.01);②治疗后,两组S-COPD患者的SGRQ各项评分及总分较治疗前均显著降低(P<0.01,P<0.05),且治疗组患者的呼吸症状、疾病影响评分和总分较对照组降低更加显著(P<0.01);③治疗后,两组支气管哮喘慢性持续期患者的SGRQ各项评分及总分较治疗前均显著降低(P<0.01),且治疗组患者的呼吸症状评分较对照组降低更加显著(P<0.01)。结论:采用中医同一方药结合西医常规疗法治疗S-COPD和支气管哮喘慢性持续期患者,能够明显改善患者的生存质量,实现"异病同治"。Objective ： To explore the effects of the same prescription on life quality of patients with stable chronic obstructive pulmonary disease （S-COPD） or bronchial asthma in chronic persistent stage. Methods： The clinical trial design of multi-central, stratified randomization, parallel control （ 1：1 ） and double blind was applied, and 276 patients with S-COPD or bronchial asthma in chronic persistent period were randomly divided into treatment group and control group with 138 cases in each group. The treatment group was treated by western medical conventional therapy plus ＂Shuchuan Formula＂ and the control group was treated by westeru medical conventional therapy plus placebo, with a course of six weeks. The quality of life of all the patients was evaluated by St . George Respiratory Questionnaire （SGRQ）. Results ： （1）After treatment, the SGRQ dimension score and the total score were decreased （ P 〈 0. 01 ） in both groups, and the scores of respiratory symptom and disease influence dimensions and the total score in treatment group were lower than those in control group （P 〈0.01 ）. （2）After treatment, the SGRQ dimension score and the total score of the patients with S-COPD were decreased （ P 〈 0.01, P 〈 0.05 ） in both groups, and the scores of respiratory symptom and disease influence dimensions and the total score in treatment group were lower than those in control group （ P 〈 0.01 ）. （3）After treatment, the SGRQ dimension score and the total score of the patients with bronchial asthma in chronic persistent period were decreased （P 〈0.01 ） in both groups, and the score of respiratory symptom dimension in treatment group was lower than that in control group （P 〈 0. 01 ）. Conclusion： Western medical conventional therapy plus ＂Shuchuan Formula＂ can obviously improve the life quality of patients with S-COPD or bronchial asthma in chronic persistent stage, and it shows the principle of ＂treating different diseases with the same therapy＂.

关 键 词：慢性阻塞性肺病 支气管哮喘 生存质量 异病同治 

分 类 号：R563.9[医药卫生—呼吸系统]