当归注射液的抗脑缺血作用研究  

Study on the Protective Effects of Angelica Injection on Cerebral Ischemia Injury

作　　者：宋书辉[1,2] 于冰[1] 徐旭[1] 赵专友[1] 汤立达[1] 

机构地区：[1]天津药物研究院释药技术与药代动力学国家重点实验室,天津300193 [2]天津中医药大学研究生院,天津300193

出　　处：《河南大学学报（自然科学版）》2012年第6期747-751,共5页Journal of Henan University:Natural Science

基　　金："十一五"国家科技支撑计划课题"当归;黄芪;大黄等区域特色中药资源利用关键技术及产业化研究"子课题(2007BAI37B06)

摘　　要：采用线栓法制造大鼠大脑中动脉阻断(Middle Cerebral Artery Occlusion,MCAO)脑卒中模型,研究当归注射液在抗脑缺血方面的药效学作用.结果显示,大鼠静脉输注(iv)当归注射液(2、4、8g/kg)可剂量依赖性改善受损的神经功能,与模型对照组相比,神经功能受损程度分别降低了10.8%、20.0%、30.8%;脑梗死面积分别缩小了26.0%、45.9%、71.3%;脑水肿抑制率分别为41.2%、82.4%、88.2%;脑膜微循环血流量均有不同程度的改善,同时证明具有抗脂质过氧化作用.以上结果表明,当归注射液具有明显的抗脑缺血保护作用,其机制可能与减轻脑缺血后海马神经元的损坏,改善脑部血液循环,促进脑生理机能的恢复,提高超氧化物歧化酶(Superoxide Dis-mutase,SOD)的活性,同时使脑缺血大鼠脑组织丙二醛(Malondialdehyde,MDA)的含量下降有关.The study is to observe Angelica injection on the function of cerebral ischemia protection.By suture method in rats induced by middle cerebral artery occlusion（Middle Cerebral Artery Occlusion,MCAO） stroke model,evaluation of Angelica injection on cerebral ischemia in terms of the pharmacodynamic effect.The rat intravenous infusion of Angelica sinensis injection（2,4,8 g/kg） may be dose-dependent improvement of impaired nerve function,compared with model control group,nerve function impairment were decreased by 10.8%,20%,30.8% respectively;cerebral infarction area is reduced by 26.0%,45.9%,71.3%;brain edema inhibition rate respectively 41.2%,82.4%,88.2%;Meningeal microcirculation blood flow were improved to different degrees,and at the same time proved to have anti-lipid peroxidation.Angelica injection has obvious anti-cerebral ischemia protective effects,its mechanism may be associated with reduced hippocampal neuronal damage after cerebral ischemia,improve cerebral blood circulation,promote the recovery of brain physiology,increased superoxide dismutase（Superoxide Dismutase,SOD） activity,while the cerebral ischemia of rat brain tissue malondialdehyde（Malondialdehyde,MDA） content related to decline.

关 键 词：当归注射液 MCAO 脑膜微循环 SOD MDA 

分 类 号：R96[医药卫生—药理学]