血管回声跟踪技术评估女性类风湿关节炎患者的肱动脉弹性  

Evaluation of brachial artery elasticity by echo-tracking technique in women with rheumatoid arthritis

作　　者：夏佳靖[1] 郑瑜[1] 刘晓庆[1] 郑丽[1] 

机构地区：[1]上海交通大学医学院附属第三人民医院超声科,201900

出　　处：《中华医学超声杂志（电子版）》2012年第12期26-29,共4页Chinese Journal of Medical Ultrasound(Electronic Edition)

基　　金：上海交通大学医学院附属第三人民医院院基金(syz09-16)

摘　　要：目的探讨应用血管回声跟踪(ET)技术检测病程大于5年的女性类风湿关节炎(RA)患者肱动脉血管弹性的价值。方法应用彩色多普勒超声及ET技术,检测32例病程大于5年的女性RA患者(RA组)和30例健康体检者(健康对照组)的颈总动脉主干、分叉处内中膜厚度(IMT)、颈动脉斑块和肱动脉单点脉搏波传导速度(PWVβ)、血流介导的血管舒张功能(FMD)。结果 RA组患者的颈总动脉主干IMT为(0.69±0.13)mm、颈总动脉分叉处IMT为(0.85±0.12)mm,与健康对照组的(0.57±0.09)mm、(0.72±0.12)mm相比均明显增厚,差异均有统计学意义(t=3.975、3.996,P均<0.01);RA组患者伴颈动脉粥样硬化斑块的比率为21.9%(7/32),高于健康对照组的6.7%(2/30),但差异无统计学意义(P=0.14,Fisher精确概率检验)。RA组患者肱动脉FMD为(7.13±5.22)%,低于健康对照组的(16.17±3.47)%,差异有统计学意义(t=-7.967,P<0.01);RA组患者肱动脉PWVβ为(8.23±1.76)m/s,高于健康对照组的(5.79±0.82)m/s,差异亦有统计学意义(t=6.902,P<0.01)。结论病程大于5年的女性RA患者肱动脉弹性功能明显下降,应用ET技术评估肱动脉弹性能为早期预防心血管疾病及临床药物治疗提供依据。Objective To investigate the application of Echo-Tracking（ET） technique in evaluation of brachial artery elasticity in female rheumatoid arthritis（RA） patients with disease durationfive years.Methods Color Doppler ultrasonography and ET technique were performed to determine common carotid intima-media thickness（IMT）,carotid bifurcation intima-media thickness,carotid plaques,brachial artery one-point pulse wave velocity calculated by β（PWVβ） and flow-mediated vasodilation（FMD） in 32 female RA patients with disease durationfive years and 30 healthy subjects（normal controls）.Results Common carotid IMT and carotid bifurcation IMT values were higher in RA patients than normal controls [（0.69±0.13）mm vs（0.57±0.09）mm,（0.85±0.12）mm vs（0.72±0.12）mm] and the differences were significant（t=3.975 and 3.996,both P〈0.01）;percentage with carotid plaques was higher in this group（21.9%） than healthy controls（6.7%）,but this difference did not reach statistical significance（P=0.14,Fisher＇s exact test）.Brachial artery FMD was significantly lower in RA patients as compared with healthy controls [（7.13±5.22）% vs（16.17±3.47）%] and the differences were significant（t=-7.967,P〈0.01）.Brachial artery PWVβ was significantly higher in RA patients as compared with healthy controls [（8.23±1.76）m/s vs（5.79±0.82）m/s]and the differences were significant（t=6.902,P〈0.01）.Conclusions Brachial artery elasticity is significantly poorer in women with RA（duration five years） as compared with normal controls.Brachial artery elasticity measured by ET technique can be a clue for early prevention and clinical treatment.

关 键 词：超声检查 多普勒 彩色 血管回声跟踪 关节炎 类风湿 肱动脉 女性 

分 类 号：R593.22[医药卫生—内科学]