急性冠脉综合征炎症介质的血浆水平及阿托伐他汀的干预作用  

Serum levels of inflammatory mediators in patients with acute cononary syndrome and intervention of Atorvastatin

作　　者：赵秀峰[1] 刘丽军[1] 马燕霞[1] 信栓力[1] 常超[1] 蔡晓清[1] 刘东燕[1] 张芙娴[1] 房宝军[2] 

机构地区：[1]河北省邯郸市第一医院心内科,河北邯郸056002 [2]河北省邯郸市第四医院外科,河北邯郸056002

出　　处：《中国医药导报》2012年第32期34-35,共2页China Medical Herald

基　　金：河北省医学科学研究重点课题计划项目(07150)

摘　　要：目的探讨血浆单核细胞趋化因子-1(MCP-1)及基质金属蛋白酶-9(MMP-9)在急性冠状动脉综合征(ACS)发病机制中的作用,以及阿托伐他汀对炎症介质的干预作用。方法入选冠状动脉造影确诊的ACS患者70例作为ACS组,冠状动脉造影结果正常受试者40例作为对照组,采用酶联免疫吸附法(ELISA)检测所有受试者术前空腹MCP-1及MMP-9血浆水平,ACS组患者口服阿托伐他汀4周后再次检测空腹MCP-1及MMP-9血浆水平。结果ACS组血浆MCP-1、MMP-9水平为(24.13±6.24)ng/L、(19.75±4.63)mg/L,与对照组(18.97±5.87)ng/L和(15.45±4.38)mg/L比较,差异有高度统计学意义(P<0.01),服用阿托伐他汀4周后ACS组血浆MCP-1及MMP-9血浆水平明显下降(P<0.01)。结论炎症反应可能参与ACS的发病过程,阿托伐他汀在抑制ACS患者炎症反应、稳定动脉粥样斑块,减少急性心血管事件方面可能有一定的作用。Objective To explore the role of monocyte chemotactic factor-1（MCP-1） and matrix metalloproteinase-9（MMP-9） in the mechanism of patients with acute cononary syndrome（ACS）,and the effects of Atorvastatin on these fac tors.Methods The patients with diagnosed ACS（ACS group,n = 70） by coronary angiography and the persons with the normal outcomes of coronary angiography（control group,n = 40） were selected.The plasma MCP-1,MMP-9 levels were detected by enzyme-linked turbidmetric and immunosorbent assay（ELISA） in all patients before surgery,the plasma MCP1,MMP-9 were detected after oral administration of Atorvastatin for 4 weeks in the patients with ACS once again.Results The levels of plasma MCP-1 [（24.13±6.24）ng/L],MMP-9 [（19.75±4.63）mg/L] in patients with ACS group were significantly increased compared with those of control group [（18.97±5.87）ng/L,（15.45±4.38）mg/L]（P〈0.01）.A significant decreased plasma MCP-1,MMP-9 were observed 4 weeks after Atorvastatin-taken（P〈0.01）.Conclusion Inflammatory response might play an important role in the pathogenesis of ACS,Atorvastatin can give better anti-inflammatory and antioxidation and better prognosis in the patients with ACS.

关 键 词：阿托伐他汀 急性冠状动脉综合征 单核细胞趋化因子-1 基质金属蛋白酶-9 

分 类 号：R541.4[医药卫生—心血管疾病]