地奥司明片治疗腰椎间盘突出症的疗效观察  

Efficacy Observation of Diosmin Tablets in the Treatment of Lubar Intervertebral Disc Protrusion

作　　者：王银河[1] 王斌[1] 俞杨[1] 朱泽章[1] 朱丽华[1] 邱勇[1] 

机构地区：[1]南京大学医学院附属鼓楼医院骨科,南京210008

出　　处：《中国药房》2012年第48期4575-4577,共3页China Pharmacy

摘　　要：目的:观察地奥司明片治疗腰椎间盘突出症的疗效和安全性。方法:将我院2011年1月-2012年1月的腰椎间盘突出症患者240例分为治疗组(150例)和对照组(90例)。治疗组绝对卧床休息半月,同时口服地奥司明片,每次2片(每片0.45g),tid,用药2周(1个疗程);对照组绝对卧床休息半月,同时以20%甘露醇注射液250mL静脉快速滴注,bid,并以10mg地塞米松加入10%葡萄糖氯化钠注射液500mL中静脉滴注,qd,用药3d后停药。比较2组患者临床疗效和不良反应。结果:治疗组总有效率达84.67%,与对照组治疗效果(87.78%)相当(P>0.05);2组治疗后腰腿痛、直腿抬高评分均较治疗前显著降低(P<0.05),组间比较差异无统计学意义(P>0.05)。2组患者均未见明显不良反应发生。结论:地奥司明片治疗腰椎间盘突出症有较明显的临床疗效,且安全性较好。OBJECTIVE： To observe the therapeutic efficacy and safety of Diosmin tablets in the treatment of lubar intervertebral disc protrusion. METHODS： 240 cases of lubar intervertebral disc protrusion in our hospital during Jan. 2011-Jan. 2012 were divided into treatment group （150 cases） and control group （90 cases）. Treatment group reposed on a bed absolutely for half month and received Diosmin tablets orally 2 pieces each time （0.45 g per piece） three times a day for 2 weeks （1 treatment course）. Control group reposed on a bed absolutely for half month and received rapid intravenous dripping of 20% Mannitol injection 200 haL, bid and intravenous dripping of dexamethasone 10 mg added into 10% Glucose and sodium chloride injection 500 mL, qd. 3 days later they stopped taking drugs. Clinical efficacy, therapeutic efficacy and adverse drug reaction were compared between 2 groups. RESULTS： Total effective rate of treatment group was 84.67 %, and therapeutic efficacy of the groups was similar to mannitol com- bined with dexamethasone （87.78%, P〉0.05）. Lumbocrural pain score and straight-leg raising score of 2 groups were decreased significantly after treatment （P〈0.05）, but there was no statistical significance （P〉0.05）. No adverse drug reaction was found in 2 groups. CONCLUSION： Diosmin tablets show obvious effect on lubar intervertebral disc protrusion with sound safety, and it is similar to mannitol combined with dexamethasone in term of clinical efficacy.

关 键 词：腰椎间盘突出症 地奥司明片 疗效 安全性 

分 类 号：R681.57[医药卫生—骨科学]