氟比洛芬酯联合丙泊酚用于人工流产手术麻醉效果的临床观察  

Clinical Observation of Flurbiprofen Axetil Combined with Propofol in Induced Abortions

作　　者：徐世琴[1] 沈晓凤[1] 汪福洲[1] 赵青松[1] 袁红梅[1] 冯善武[1] 韩翠翠[1] 崔晓花[1] 陈丽丽[1] 吴海波[1] 

机构地区：[1]南京医科大学附属南京妇幼保健院麻醉科,南京210004

出　　处：《中国药房》2012年第48期4580-4582,共3页China Pharmacy

摘　　要：目的:观察氟比洛芬酯联合丙泊酚用于人工流产手术的麻醉效果和安全性。方法:将2000例要求行无痛人工流产手术的患者随机均分为氟比洛芬酯联合丙泊酚组(观察组)和丙泊酚组(对照组)。观察组先缓慢静脉注射氟比洛芬酯50mg,10min后静脉注射丙泊酚2.5mg.kg-1;对照组单独静脉注射丙泊酚2.5mg.kg-1。记录麻醉前和手术开始时的血压、心率、血氧饱和度,记录起效时间、苏醒时间、手术时间、丙泊酚总用药量、术中出血量、麻醉效果、唤醒后兴奋躁动的例数、术后子宫收缩痛评分、不良反应及患者的满意度评分。结果:2组患者术中出血量比较,差异无统计学意义(P>0.05)。观察组麻醉效果优于对照组,丙泊酚总用药量少于对照组,患者苏醒时间短于对照组,差异均有统计学意义(P<0.01)。观察组苏醒期躁动的发生率低于对照组,术后视觉模拟评分法(VAS)评分低于对照组,满意度评分高于对照组,差异均有统计学意义(P<0.01)。结论:在人工流产手术中应用氟比洛芬酯联合丙泊酚具有良好的麻醉效果,不增加患者术中出血量,患者满意度较高。OBJECTIVE： To investigate the anesthetic effect and safety of flurbiprofen axetil combined with propofol on the induced abortion. METHODS： 2 000 patients undergoing induced abortion were randomly divided into flurbiprofen axetil combined with propofol group （observation group） and propofol group （control group） with 1 000 patients in each group. Observation group was administrated with flurbiprofen axetil 50 mg intravenously first and 10 minutes later followed with propofol 2.5 mg·kg^-1. Control group was administrated with 2.5 mg·kg^-1 propofol. BP, HR and SpO2 were recorded before anaesthesia and at the beginning of surgery. Onset time, recovery time, operation time, amount of propofol, intraoperative bleeding volume, anesthetic efficacy, case number of excitement and dysphoria after awakening, postoperative uterine contraction pain score, adverse drug reaction and the degree of satisfaction score were recorded. RESULTS： There was no significant difference in intraoperative bleeding volume between 2 groups （P〉0.05）. Anesthetic efficacy of observation group was significantly better than that of control group, and consumption amount of propofol in observation group was lower than in control group. Recovery time of observation group was shorter than that of control group, there was statistical significance （P〈0.01）. The incidence of dysphoria after awakening in observation group was lower than in control group, and postoperative VAS score were significantly lower than in control group. The score of satisfaction degree was significantly higher in observation group than in control group, there was statistical significance （P〈0.01）. CONCLUSION： Flurbiprofen axetil combined with propofol is effective for anaesthesia of induced abortion. It is a safe and effective scheme because of controlling intraoperative bleeding volume and obtaining sound satisfaction degree.

关 键 词：氟比洛芬酯 丙泊酚 人工流产 

分 类 号：R614.2[医药卫生—麻醉学]