布托啡诺、哌替啶与曲马多治疗围麻醉期病人寒战的效果  

A comparison among butorphanol,pethidine and tramadol in treating perioperative chilling

作　　者：曹亚[1] 鲁卫华[1] 柳兆芳[1] 鲁美静[1] 

机构地区：[1]皖南医学院附属弋矶山医院麻醉科

出　　处：《中国临床药理学与治疗学》2012年第11期1276-1278,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:观察布托啡诺、哌替啶与曲马多三种药物治疗围麻醉期病人寒战的效果。方法:60例ASAⅠ～Ⅱ级麻醉期间发生寒战反应的病人,随机分为三组,每组20例:布托啡诺组,静脉注射布托啡诺0.02mg/kg;哌替啶组,静脉注射哌替啶0.5mg/kg;曲马多组,静脉注射曲马多1mg/kg。观察寒战程度及治疗效果,用药后镇静评分及不良反应。结果:布托啡诺组和曲马多组寒战治疗有效率高于哌替啶组(P<0.01);哌替啶组和曲马多组的镇静评分显著高于布托啡诺组(P<0.05);曲马多组恶心呕吐发生率高于哌替啶组和布托啡诺组(P<0.05)。结论:布托啡诺与曲马多可有效控制麻醉后的寒战反应,但布托啡诺镇静作用较强,而曲马多增加恶心呕吐发生率,临床上应根据患者的情况合理应用相应药物。AIM. To study the effects of bu torphanol , pethidine and tramadol in treatment of patients with perioperative shivering. METH- ODS： Sixty ASA Ⅰ-Ⅱ patients with shivering response during anesthesia were randomly divid ed into three groups（n= 20） ： butorphanol group （group B）, intravenous injection of butorphanol 0.02 mg/kg; pethidine group （group P）, intra venous injection of pethidine 0.5 mg/kg; and tramadol group （group T）, intravenous tramad ol 1 mg/kg. Observed the degree and time of oc- currence of shivering, shivering response after treatment and adverse effect in sedation score. RESULTS： Butorphanol group and tramadol group were effective than pethidine group intreatment of shivering （P 〈0.01）. Butorphanol group was significantly higher than tramadol group and pethidine group in sedation （P 〈0.05）. Tramadol group was significantly higher than pethidine group and butorphanol group in incidence of nausea and vomiting （P 〈0.05）. CONCLUSION. Butorphanol and tramadol can effectively treat perioperative shivering,but clin- ical patients should be reasonable select different drugs according to particular case.

关 键 词：布托啡诺 曲马多 哌替啶 寒战 

分 类 号：R614[医药卫生—麻醉学]