Versatility of the translational machinery during stress： changing partners to keep dancing  

作　　者：Fatima Gebauer 

机构地区：[1]Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG-UPF), Dr Aiguader 88, 08003-Bar-celona, Spain

出　　处：《Cell Research》2012年第12期1634-1636,共3页细胞研究（英文版）

摘　　要：Cap-dependent translation is initi- ated by the binding of elF4E to the cap structure at the 5＇ end of mRNAs. During hypoxic stress, global translation decreases because elF4E is inac- tivated. In a recent article in Nature, Lee and colleagues show that residual hypoxic translation is maintained by a specialized isoform of elF4E, which binds to target mRNAs in complex with a hypoxia-induced RNP.

关 键 词：翻译机器 合作伙伴 多功能性 应激状态 跳舞 mRNA 依赖性 氧应激 

分 类 号：O613.71[理学—无机化学] TN949.28[理学—化学]