Mechanisms involved in the Abacavir-mediated hypersensitivity syndrome  

作　　者：Anuska Llano Christian Brander 

机构地区：[1]Irsicaixa AIDS Research Institute- HIVACAT, Hospital Universitari Germans Trias i Pujol, Badalona, Spain [2]Universitat Autonoma de Barcelona, Hospital Universitari Germans Trias i Pujol, Badalona, Spain [3]Institucio Catalana de Reserca i Estudis Avancats (ICREA) Barcelona, Spain

出　　处：《Cell Research》2012年第12期1637-1639,共3页细胞研究（英文版）

摘　　要：The potentially life-threatening adverse reactions to Abavacir （ABC）, a nucleoside analog reverse transcriptase inhibitor for the treatment of H1V infection, have been known for several years to be limited to individu- als expressing the HLA-B＊57：01 gene. Why the ABC hypersensitivity syn- drome is only seen in HLA-B＊57：01- expressing subjects and what the precise mechanisms underlying this intolerance are remain however con- troversial. A series of recent studies, particularly a study by Illing et al. recently published in Nature, now answer some of these questions and offer new opportunities to better understand autoimmune disorders and prevent adverse reactions to other drugs.

关 键 词：超敏反应 综合征 机制 自身免疫性疾病 HLA-B 介导 不良反应 核苷类似物 

分 类 号：Q2[生物学—细胞生物学] TQ047[化学工程]