Effect of Mixed Solvent on Fabrication, Morphology and Monodispersity of Microspheres with Hydrophobic Poly(butyl methacrylate) Shells  

作　　者：肖新才 卢程 

机构地区：[1]School of Pharmacy,South-Central University for Nationalities [2]School Hospital,Wuhan Institute of Technology

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2012年第6期1048-1052,共5页武汉理工大学学报（材料科学英文版）

基　　金：Funded by the National Natural Science Foundation of China (No. 20976202)

摘　　要：Monodisperse microspheres （mean diameter 200-300 nm） with polystyrene cores and poly（acrylamide-co-butyl methacrylate） shells were prepared by using a free radical polymerization method. Moreover, the effect of mixed solvent on the preparation, morphology and monodispersity was investigated. The experimental results showed that solubility parameter of butyl methacrylate and solvent affected mainly the molding of monodisperse core-shell microspheres. When the microspheres were fabricated in a sequential synthesis process, addition of hydrophilic and organic solvent including butyl methacrylate led to spherical degree of the particles becoming worse, and the mean diameter of the microspheres decreased and the monodispersity became better with increasing the crosslinker methylenebisacrylamide dosage.Monodisperse microspheres （mean diameter 200-300 nm） with polystyrene cores and poly（acrylamide-co-butyl methacrylate） shells were prepared by using a free radical polymerization method. Moreover, the effect of mixed solvent on the preparation, morphology and monodispersity was investigated. The experimental results showed that solubility parameter of butyl methacrylate and solvent affected mainly the molding of monodisperse core-shell microspheres. When the microspheres were fabricated in a sequential synthesis process, addition of hydrophilic and organic solvent including butyl methacrylate led to spherical degree of the particles becoming worse, and the mean diameter of the microspheres decreased and the monodispersity became better with increasing the crosslinker methylenebisacrylamide dosage.

关 键 词：mixed solvent MONODISPERSITY core-shell structure MORPHOLOGY 

分 类 号：O631.3[理学—高分子化学]