Preparation and Drug-release Behavior of β-TCP Ceramics Drug Carrier in vitro  

作　　者：张启焕 YAN Xin YAN Yuhua DAI Honglian JIANG Xin LI Shipu 

机构地区：[1]College of Chemical and Biological Engineering,Yancheng Institute of Technology [2]Biomedical Materials and Engineering Center,Wuhan University of Technology,Wuhan 430070,China

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2012年第6期1058-1060,共3页武汉理工大学学报（材料科学英文版）

基　　金：Funded by the "973" Chinese National Key Fundamental Research and Development Program (No.G1999064701);the Research Fund of Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province (AE201037)

摘　　要：β-TCP ceramics drug carrier was first prepared and characterized. SEM showed that β-TCP carrier was in porous amorphous structure with diameters around 10 μm. The physical properties including apparent porosity, volume-weight, tensile strength and the permeability were measured and the results indicated those properties fit the clinical usage of β-TCP drug carrier. Furthermore, drug release experiment in vitro showed that the carrier could prolong drug release in simulated body fluid which provides basis for the clinical use of β-TCP ceramics as drug carrier.β-TCP ceramics drug carrier was first prepared and characterized. SEM showed that β-TCP carrier was in porous amorphous structure with diameters around 10 μm. The physical properties including apparent porosity, volume-weight, tensile strength and the permeability were measured and the results indicated those properties fit the clinical usage of β-TCP drug carrier. Furthermore, drug release experiment in vitro showed that the carrier could prolong drug release in simulated body fluid which provides basis for the clinical use of β-TCP ceramics as drug carrier.

关 键 词：β-TCP ceramics drug carrier physicochemical properties drug release clinical use 

分 类 号：TQ460.1[化学工程—制药化工]