鸡源弓形虫治疗药物的筛选  

Screening of drugs for treatingToxoplasma gondiiinfection in chicken

作　　者：王帅[1] 赵光伟[1] 谢青 王望 张梦 Hassan I A 李锐 李祥瑞[1] 

机构地区：[1]南京农业大学动物医学院,江苏南京210095

出　　处：《中国兽医科学》2012年第11期1190-1194,共5页Chinese Veterinary Science

基　　金：农业部公益性行业专项(200903036)

摘　　要：为了筛选能有效治疗鸡弓形虫病的药物,用刚地弓形虫RH和JS株速殖子,按1×104和1.5×108分别腹腔接种ICR小鼠和鸡,接种后4h用药组通过灌服或饮水给药,连续用药5d,接种后20d或10d结束试验,根据存活率、平均存活时间等指标得出疗效。在抗小鼠弓形虫感染试验中,磺胺氯吡嗪钠+甲氧苄啶组的治疗效果最佳,阿奇霉素次之,其余药物的抗弓形虫作用不明显。在抗鸡弓形虫感染试验中,阿奇霉素和磺胺氯吡嗪钠+甲氧苄啶组均能显著提高雏鸡的存活率,前者(44.4%)略高于磺胺氯吡嗪钠+甲氧苄啶组(33.3%),但两者无明显差异(P>0.05)。结果表明,阿奇霉素和磺胺氯吡嗪钠联合甲氧苄啶对鸡弓形虫感染均有明显的治疗效果。For the purpose of screening the effective drugs on chicken toxoplasmosis, 1 × 10^4 tachyzoites of RH and JS isolates of Tozoplasma gondii were intraperitoneally（i, p. ） inoculated in mice,while 1.5 × 10^8 tachyzoites of JS isolates were infected i. p. in chicks. Four hours later, all the target animals were administrated orally with different drugs. All these drugs were given once a day and treated for 5 days consecutively. After that, the clinical signs of each animal were checked every day and the survival time was recorded. The experiment was ended at 20 d post the infection for mice and 10 d for chicks. According to the survival rate and the average survival time, all these drugs were evaluated for their therapeutic effects. The results showed that the most effective therapy strategy was the combination of sulfachloropyrazine sodium （SPZ） and trimethoprim（TMP） on the mice, and azithromycin （AZM） was also effective. However, the other drugs had no significantly effectiveness. When compared the effects of anti-T, gondii infection on chicks, both AZM and the combination of SPZ and TMP could notablely improve the survival rate of infec- ted chicks. The survival rate（44. 4%） of the former was slighly higher than that of the latter（33.3%）, but no significant differences were found between these two groups. In conclusion, AZM and the combination of SPZ and TMP were the effective drugs for the treatments of chicken toxoplasmosis.

关 键 词：鸡 弓形虫 治疗药物 

分 类 号：S852.723[农业科学—基础兽医学]