早泄患者盐酸舍曲林治疗前后血清瘦素水平的变化  

Changes of serum leptin levels in patients with premature ejaculation after sertraline treatment

作　　者：汤坤龙[1] 王宝龙[1] 杨琳[2] 李黎明[1] 周勇[1] 杨长海[1] 

机构地区：[1]天津医科大学总医院泌尿外科,300052 [2]天津医科大学总医院 妇产科生殖医学中心,300052

出　　处：《中华全科医师杂志》2012年第12期921-923,共3页Chinese Journal of General Practitioners

基　　金：天津医科大学科学基金资助（2011KY02）

摘　　要：对59例门诊早泄（PE）患者，予盐酸舍曲林治疗8周，观察治疗前后血浆瘦素水平的变化，同时评估射精潜伏期（IELT）、中国早泄患者性功能评价表（CIPE）评分的变化，并行相关性分析。59例PE患者治疗前血浆瘦素水平明显高于64例正常对照者，而IELT及CIPE评分远低于正常对照者；盐酸舍曲林治疗8周后，PE患者IELT及CIPE评分明显上升，血浆瘦素水平下降。表明血浆高水平瘦素是PE患者的生物学指标，其测定对临床诊断PE和评估疗效具有参考意义。Fifty nine patients with premature ejaculation （PE） received sertraline treatment for 8 weeks. The average intravaginal ejaculation latency time （IELT） and the scores of Chinese index of premature ejaculation （CIPE） were evaluated and the fasting serum leptin levels were measured before and after treatment, all the values were compared with those of 64 normal male controls. The serum leptin levels were higher, the IELT and CIPE scores were lower in PE patients than those in normal controls before treatment. After 8 weeks of treatment with sertraline, the levels of serum leptin in PE patients decreased to normal levels, CIPE and IELT increased. The results indicate that serum leptin can be used as a bioindicator for diagnosis of premature ejaculation and assessment of therapeutic efficacy in PE patients.

关 键 词：早泄 瘦素 

分 类 号：R698[医药卫生—泌尿科学]