胃肠宁对脾虚大鼠胃肠激素和炎性细胞因子的影响  

Influence of Weichangning Decoction on gastrointestinal hormone and inflammatory cytokines of spleen-deficiency rats

作　　者：郭延生[1] 魏彦明[2] 华永丽[2] 杨洪申[2] 

机构地区：[1]宁夏大学农学院,宁夏银川750021 [2]甘肃农业大学动物医学院

出　　处：《中兽医医药杂志》2012年第6期13-16,共4页Journal of Traditional Chinese Veterinary Medicine

基　　金：宁夏大学科学研究基金资助项目(项目编号:ZR1135)

摘　　要：目的:探讨胃肠宁对脾虚证动物胃肠激素和炎性细胞因子的影响。方法:采用苦寒泻下法复制大鼠脾虚证模型,研究胃肠宁对脾虚大鼠血清中IL-10、IL-1β及回肠始段SP、VIP含量的影响。结果:脾虚证大鼠血清中IL-10水平显著降低(P<0.05),IL-1β水平显著升高(P<0.05),胃肠宁能在一定程度上恢复IL-10和IL-1β含量,但与自然康复组相比差异不显著(P>0.05);脾虚证大鼠回肠始段SP含量显著升高(P<0.05),VIP含量显著降低(P<0.05),胃肠宁能显著恢复脾虚大鼠回肠始段SP和VIP含量(P>0.05)。结论:胃肠宁对脾虚证具有较好的治疗作用,其作用机制主要是能显著改善脾虚大鼠回肠始段SP和VIP水平。Objective： To further study the efficacy of Weichangni Decoction on spleen deficiency syndrome. Methods： The model of rat with spleen deficiency syndrome was made by the method of purgation with drugs of bitter flavour and cold nature,and the influence of Weichangning Decoction on the content of IL-10, IL-1β in serum and SP, VIP in initial part of ileum of spleen deficiency rats was studied. Results：The content of IL-10 in serum of spleen deficiency rats was significantly decreased （P〈0.05）and IL-Iβ was significantly increased （P〈0.05）.Weichangning could recover the content of IL-10 and IL-1β of spleen deficiency rats in some extent, which had no signifieant difference from natural recovery group （P〉0.05）： the content of SP in initial part of ileum of spleen deficiency rats was significantly increased （P〈0.05）, and VIP was significantly decreased （P〈0.05）.Weichangning could significantly recover the content of SP and VIP in initial part of ileum of spleen deficienc） rats （P〉0.05）. Conclusion： Weichangning had better efficacy on spleen deficiency syndrome, and the main mechanism was that Weichangning can regulate the content of SP and VIP in initial part of ileum of spleen deficiency rats.

关 键 词：胃肠宁 脾虚大鼠 胃肠激素 炎性细胞因子 

分 类 号：S853.74[农业科学—临床兽医学]