瓜环[n](n=7,8)与盐酸法舒地尔的相互作用研究  

Interaction between Cucurbit[n]uril(n=7,8) and Fasudil Hydrochloride Studied by NMR Spectroscopy

作　　者：陈秀丽[1] 朱卫国[1] 姜松[1] 杨春雪[1] 邹大鹏[1] 

机构地区：[1]郑州大学化学与分子工程学院,河南省化学生物与有机化学重点实验室,河南郑州450052

出　　处：《波谱学杂志》2012年第4期554-563,共10页Chinese Journal of Magnetic Resonance

基　　金：河南省基础与前沿技术研究计划资助项目(122300413203)

摘　　要：分别以NMR技术、电喷雾质谱、紫外光谱和红外光谱等分析方法考察了瓜环[n](n=7,8)与盐酸法舒地尔的相互作用.实验结果显示,盐酸法舒地尔与两种瓜环都形成了1∶1的包结配合物,但其主客体配合物的作用模式随着瓜环空腔大小的不同而各不相同.通过紫外吸收光谱法计算出瓜环[n](n=7,8)与盐酸法舒地尔的包结常数分别为2 524L/mol,1 216L/mol,其范围在200L/mol～10 000L/mol之内,这说明瓜环对盐酸法舒地尔具有潜在的药物缓释作用.The host-guest chemistry of systems containing fasudil hydrochloride （FSDE） and cucurbit[n]uril （CB[n], n=7, 8） was investigated by NMR, ESI-MS, UV-Vis and IR spectroscopy. The experiment results indicated that the guest fasudil hydrochloride and CB[n] （n=7, 8） host could form a stable 1 ： 1 （molar ratio） inclusion complex, in which the positions of CB[7] and CB[8] were different because of the sizes of their cavities. The inclusion constant of fasudil hydrochloride with CB[7] and CB[8] was 2 524 L/mol and 1 216 L/mol, respectively. The binding constant was in the range of 200 L/ mol-10 000 L/mol, indicating that CB[7] and CB[8] could be used as possible slow-released agents.

关 键 词：瓜环[n](n=7 8) 盐酸法舒地尔 包结配合物 NMR技术 

分 类 号：O482.53[理学—固体物理]