The miRNAs of Herpes Simplex Virus(HSV)  

作　　者：Le Sun Qihan Li 

机构地区：[1]Department of Viral Immunology,Institute of Medical Biology,Chinese Academy of Medicine Science,PekingUnion Medical College,Kunming 650118,China

出　　处：《Virologica Sinica》2012年第6期333-338,共6页中国病毒学（英文版）

基　　金：supported by the National Natural Sciences Foundation of China(No.30670094 and 30700028);Youth Science Research Foundation of PUMC(No.2012X23)

摘　　要：Herpes simplex virus (HSV) is a group of common human pathogens with two serotypes HSV-1 and HSV-2.The prevalence of HSV is worldwide.It primarily infects humans through epithelial cells,when it introduces a latent infection into the nervous system.During viral latency,only a region known as the latency-associated transcript (LAT) is expressed.The discovery of HSV miRNAs helps to draw a larger picture of the infection and pathogenesis of the virus.This review summarizes miRNAs found in HSV-1 and HSV-2 so far.The functional studies of miRNAs in HSV to date indicate that they play a stage-specific role coordinated with viral proteins to maintain the virus life cycle.Herpes simplex virus （HSV） is a group of common human pathogens with two serotypes HSV-1 and HSV-2. The prevalence of HSV is worldwide. It primarily infects humans through epithelial cells, when it introduces a latent infection into the nervous system. During viral latency, only a region known as the latency-associated transcript （LAT） is expressed. The discovery of HSV miRNAs helps to draw a larger picture of the infection and pathogenesis of the virus. This review summarizes miRNAs found in HSV-1 and HSV-2 so far. The functional studies of miRNAs in HSV to date indicate that they play a stage-specific role coordinated with viral proteins to maintain the virus life cycle.

关 键 词：Herpes simplex virus （HSV） MIRNAS Latency-associated transcript （LAT） 

分 类 号：S858.285.3[农业科学—临床兽医学] Q78[农业科学—兽医学]