经典BMP信号通路与哺乳动物肺器官发育  

Canonical BMP Signaling Pathway And Mammalian Lung Development

作　　者：肖爱平[1] 滕鸿琦[1] 李小兵[1] 张明凤[1] 

机构地区：[1]福建省发育与神经生物学重点实验室,福建师范大学生命科学学院,福州350108

出　　处：《福建畜牧兽医》2012年第6期19-26,共8页Fujian Journal of Animal Husbandry and Veterinary medicine

摘　　要：肺器官发育是上皮和间充质相互作用的过程,由多条信号通路共同调控。已知经典BMP信号通路调控了细胞的增殖、凋亡及分化过程,对哺乳动物肺器官形态发生极为重要。在小鼠等模式生物上研究发现,它参与了哺乳动物肺器官发育的调控过程。本文综合了近年来经典BMP信号通路成员在哺乳动物肺器官发育过程中的表达变化、作用功能及表达异常可能诱发的肺部疾病,以期为研究经典BMP信号通路调控人类肺器官发育的分子机制及相关肺部疾病的诊治奠定基础。Lung development is a consequence of interaction between epithelium and mesenchyme, which is regulated by several signaling pathways. It is well known that the canonical BMP signal pathway plays an important role in the regulation of cell proliferation, apoptosis and differentiation. They are also found to play pivotal roles in morphogenesis of mammalian lung. Recent studies on model organisms, such as mouse and rat, verified that the canonical BMP signal pathway participated in the regulation of mammalian lung development. This review has summarized the main recent research findings on the role of canonical BMP signaling components in the regulation of mammalian lung development. The gene expression and function in all members of canonical BMP signaling pathway, and the possible lung diseases induced by abnormal expression of canonical BMP signaling components during the mammalian lung development were emphasized to state. It＇s anticipated to provide valuable information for further illustration of the molecular mechanisms of BMP signals in the regulation of human lung development, as well as will be in favor of finding the way to diagnose and cure human lung diseases.

关 键 词：肺 器官发育 BMP信号通路 SMADS 

分 类 号：S852.21[农业科学—基础兽医学]