焦磷酸钙结晶沉积症20例的临床病理分析  

Calcium pyrophosphate dihydrate crystal deposition disease： a clinicopathologic analysis of 20 cases

作　　者：房惠琼[1] 李启明[1] 黄耀渠[2] 邢基斯[3] 毛荣军[1] 谢乐[1] 

机构地区：[1]广东省佛山市中医院病理科,528000 [2]广东省佛山市中医院放射科,528000 [3]广东省佛山市中医院骨科,528000

出　　处：《中华病理学杂志》2012年第12期828-832,共5页Chinese Journal of Pathology

摘　　要：目的探讨焦磷酸钙结晶沉积症的临床及病理学特征。方法回顾性分析20例焦磷酸钙结晶沉积症的临床资料、影像学表现和病理组织学形态的特点。结果焦磷酸钙结晶沉积症女性多见，好发于关节滑膜，尤其膝关节，临床表现为关节炎为主，具有多样性；影像学的特征性改变是异常钙化和关节间隙损害；组织学镜下见滑膜组织间质内多灶状紫蓝色钙盐沉积，形态可为细颗粒状、针芒状或菱形结晶。结论焦磷酸钙结晶沉积症临床表现多样，根据影像学的异常钙化、关节间隙损害和病理见紫蓝色钙盐沉积可明确诊断。Objective To investigate the clinicopathologic features of calcium pyrophosphate dihydrate crystal deposition disease （CPPD-CDD）. Methods The clinical and pathologic profiles were retrospectively analysed in 20 cases of CPPD-CDD. Results CPPD-CDD was far more common in women, most frequently involving joints, especially the knees and presenting with various arthrisis. Abnormally calcified and the articular damages were characteristic features by imageing. Histologically, muhifocal indigo granular calcinosis was seen in synovium and sometimes appeared as needle-shaped or rhomboid crystals, which characterized the CPPD. Conclusions Though clinical symptoms of CPPD are quite variable, the definite diagnosis can be made by the abnormal calcification and joint damage radiographically and the indigo CPPD crystals histopathologieally.

关 键 词：软骨疾病 焦磷酸钙 软骨钙质沉着症 

分 类 号：R684[医药卫生—骨科学]