电针合药物治疗帕金森病伴发抑郁症及对患者血清BDNF的影响  

Parkinson's disease combined with depression treated with electroacupuncture and medication and its effect on serum BDNF

作　　者：夏毅[1] 王海东[1] 丁莹[1] 康冰[1] 刘卫国[2] 

机构地区：[1]南京医科大学附属脑科医院中医科,江苏南京210029 [2]南京医科大学附属脑科医院神经内科,江苏南京210029

出　　处：《中国针灸》2012年第12期1071-1074,共4页Chinese Acupuncture & Moxibustion

基　　金：南京医科大学科技发展基金面上项目:2010 NJMU 072

摘　　要：目的:验证电针合药物治疗帕金森病伴发抑郁症的疗效并探讨其作用机制。方法:将60例帕金森病伴发抑郁症患者随机分为针药组和西药组,每组30例。两组均采用常规治疗,口服美多巴、氟西汀,针药组在此基础上行电针疗法,穴取百会、印堂、四神聪、太冲、三阴交等。对比观察两组治疗前与治疗3个月后血清脑源性神经营养因子(BDNF)水平和汉密尔顿抑郁量表(HAMD)评分,并评定两组疗效。结果:两组治疗后血清BDNF水平较治疗前均显著提高(均P<0.05),且针药组优于西药组(P<0.05);两组治疗后HAMD评分较治疗前显著降低(均P<0.05),且针药组优于西药组(P<0.05)。针药组总有效率为90.0%(27/30),优于西药组的83.3%(25/30,P<0.05)。结论:电针合药物治疗帕金森病伴发抑郁症疗效显著,能有效调节患者血清中BDNF水平,从而缓解抑郁症状,其疗效优于单纯药物治疗。Objective To verify the efficacy on Parkinson＇s disease combined with depression treated with electroacupuncture and medication and to explore the therapeutic mechanism.Methods Sixty cases of Parkinson＇s disease combined with depression were randomized into an acupuncture ＋ medication group and a medication group,30 cases in each one.The conventional therapeutic program of oral administration of madopar and fluoxetine was applied in both groups.In the acupuncture ＋ medication group,on the basic treatment as the above,electroacupuncture was applied to Baihui（GV 20）,Yintang（EX-HN 3）,Sishencong（EX-HN 1）,Taichong（LR 3） and Sanyinjiao（SP 6）,etc.The level of the serum brain-derived neurotrophic factor（BDNF） and the score of Ha-milton depression scale（HAMD） were observed and compared before treatment and after 3 months of treatment.The efficacy was assessed in two groups.Results The level of BDFN was improved significantly after treatment as compared with that before treatment in two groups（both P0.05） and the result in the acupuncture ＋ medication group was superior to the medication group（P0.05）.HAMD scores were reduced significantly after treatment as compared with those before treatment in two groups（both P0.05） and the result in the acupuncture ＋ medication group was superior to the medication group（P0.05）.The total effective rate was 90.0%（27/30） in the acupuncture ＋ medication group,which was better than 83.3%（25/30） in the medication group（P0.05）.Conclusion The combined therapy of electroacupuncture and medication achieves the significant efficacy on Parkinson＇s disease combined with depression.This therapy regulates effectively serum BDNF level,relieves depression symptoms of the patients.The efficacy of electroacupuncture combined with medication is superior to the simple medication.

关 键 词：帕金森病 抑郁症 电针 脑源性神经营养因子 

分 类 号：R246.6[医药卫生—针灸推拿学]