合并高三酰甘油腰围表型的冠心病患者冠状动脉病变特点及相关危险因素的临床研究  

The relationship between waist circumference and triglyceride product,inflammatory cytokines and the characteristics of coronary artery disease in CHD patients

作　　者：林志[1] 张戈[1] 刘小永[1] 杨瑞丰[1] 

机构地区：[1]昆明医学院第二附属医院心内科,昆明650101

出　　处：《重庆医学》2012年第34期3614-3616,共3页Chongqing medicine

摘　　要：目的探讨合并高三酰甘油腰围表型(HTWP)的冠心病(CHD)患者冠状动脉病变特点及其与相关危险因素的关系。方法收集该院经冠状动脉造影证实至少有1支血管狭窄大于或等于50%的CHD患者共125例,其中合并HTWP 60例(实验组),不合并的有65例(对照组)。结果与对照组相比,实验组患者冠状动脉病变积分更高,实验组患者腰围三酰甘油(TG)乘积指数、白细胞介素-6(IL-6)与冠脉病变积分相关,偏回归系数分别为0.228(P=0.035)和0.541(P<0.001)。结论合并HTWP的CHD患者冠脉病变更重,而且腰围TG乘积指数、IL-6与冠脉病变严重程度密切相关。Objective To investigate the characteristics of coronary artery disease in CHD patients with hypertriglyceridemic waist phenotype and the relationship with risk factors. Methods We collected 125 CHD patients with at least one coronary angiography ≥ 50%,among which there is 60 cases of hyperglyceridemic waist phenotype with CHD, 65 cases of CHD. Results Compared with the control group,high triglyceridemic waist phenotype with coronary heart disease has a higher degree of coronary artery score. Waist circumference,triglyceride product,interleukin 6 were associated with coronary artery score in CHD patients with hypertriglyceridemic waist phenotype,partial regression coefficients were 0. 228（P=0. 035） ;0. 541（P〈0. 001）. Conclusion Coronary artery disease patients with hypertriglyeeridemic waist phenotype suggests more severe damage of coronary artery. Waist circumference and triglyceride and IL 6 are closely related with the severity of coronary artery.

关 键 词：高三酰甘油腰围表型 腰围三酰甘油乘积指数 白细胞介素6 冠心病 冠脉病变积、分 

分 类 号：R541.4[医药卫生—心血管疾病]