肌钙蛋白T对腹膜透析患者预后的预测作用  

Assessment of serum cardiac troponin T in predicting peritoneal dialysis outcome

作　　者：李瑾娜 程允就[2] 吴素华[2] 

机构地区：[1]湖南省衡阳市第一人民医院,湖南衡阳421002 [2]中山大学附属第一医院

出　　处：《山东医药》2012年第40期26-28,共3页Shandong Medical Journal

基　　金：教育部留学回国人员基金资助项目(200724)

摘　　要：目的探讨腹膜透析患者血清心肌肌钙蛋白T(cTnT)对其心脑血管疾病及死亡的预测价值。方法选择衡阳市第一人民医院行规律腹膜透析患者214例,检测透析前后生化及心脏形态改变。随访3 a或至其死亡,记录随访期间患者死亡及发生心脑血管事件情况。结果 cTnT与糖尿病、心脑血管病史、hs-CRP、左心室重量指数(LVMI)呈正相关,与eGFR、左室射血分数呈负相关。生存分析显示cTnT≥0.1μg/L组初发心脑血管事件、心脑血管事件死亡率及全因死亡率明显升高;COX比例风险回归模型分析示cTnT可预测初发心脑血管事件、心脑血管事件死亡率及全因死亡率,并独立于hs-CRP、eGFR、LVMI、左室射血分数、透析时间因素之外。结论 cTnT为腹膜透析患者初发心脑血管事件、心脑血管病死亡事件及全因死亡事件的独立预测因子。Objective To investigate whether cardiac troponin T （cTnT） independently predicts outcome in chronic peritoneal dialysis （PD） with end-stage renal disease. Methods Baseline eTnT, echocardiography and biochemical characteristics were assessed in 214 chronic PD patients who were followed prospectively for 3 years or until death. Results Increased cTnT correlated significantly with history of diabetes and cardiovascular events （CVE）, increase of high-sensitivity CRP and left ventricular mass index （LVMI） , decrease of eGFR and left ventrieular ejection fraction. Kaplan-Meier survival curve analysis revealed cTnT≥0.1 μg/L was linked to fatal and nonfatal CVE, all-cause mortality and cardiovascular death. Muhivariable COX regression analysis indicated cTnT was independently predictive of fatal and nonfatal CVEs, allcause mortality, cardiovascular death. Conclusion cTnT is an independent predictor of long term mortality, cardiovascular death and events in PD patients.

关 键 词：肌钙蛋白T 腹膜透析 心脑血管疾病 死亡率 

分 类 号：R459.5[医药卫生—治疗学]